The Emerging Role of N6-Methyladenosine RNA Methylation as Regulators in Cancer Therapy and Drug Resistance.

N6-methyladenosine (mA) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs. Typically, mA RNA methylation is catalyzed by the RNA methyltransferases (writers), is removed by its demethylases (erasers), and interacts with mA-binding proteins (readers). Accumulating evidence shows that abnormal changes in the mA levels of these regulators are increasingly associated with human tumorigenesis and drug resistance. However, the molecular mechanisms underlying mA RNA methylation in tumor occurrence and development have not been comprehensively clarified. We reviewed the recent findings on biological regulation of mA RNA methylation and summarized its potential therapeutic strategies in various human cancers.