Function and evolution of RNA N6-methyladenosine modification.

N6-methyladenosine (mA) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. mA modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by mA binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers). Accumulating evidence shows that mA RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses. In this review, we mainly summarize and discuss the functional relevance and importance of mA modification in cellular processes.