Song Wei, Ma Tao, Cheng Qianyue, Wen Pengfei, Wu Jiayuan, Hao Linjie, Zhang Binfei, Wang Yakang, Wang Qiuyuan, Zhang Yumin
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Shaanxi, China.
Xi'an Medical University, Shaanxi, China.
Front Med (Lausanne). 2022 Apr 7;9:837163. doi: 10.3389/fmed.2022.837163. eCollection 2022.
Venous thromboembolism (VTE) after hip or knee arthroplasty has attracted increasing attention over the past few decades. However, there is no bibliometric report on the publications in this field. The purpose of this study was to analyze the global research status, hotspots, and trends in VTE after arthroplasty.
All articles about VTE research after hip or knee arthroplasty from 1990 to 2021 were retrieved from the Web of Science Core Collection database. The information of each article including citation, title, author, journal, country, institution, keywords, and level of evidence was extracted for bibliometric analysis.
A total of 1,245 original articles from 53 countries and 603 institutions were retrieved. The USA contributed most with 457 articles, followed by England and Canada. McMaster University in Canada was the leading institution for publications. The journals with the highest output and citation were the Journal of Arthroplasty and the Thrombosis and Haemostasis, respectively. The median number of citations was significantly different among the levels of evidence ( = 128.957, < 0.001). The research hotspots switched from VTE diagnosis and heparin to factor Xa inhibitors (fondaparinux, rivaroxaban, apixaban) and direct thrombin inhibitors (dabigatran etexilate, ximelagatran), and finally to aspirin, risk factor studies, which can be observed from the keyword analysis and co-cited reference cluster analysis.
This study observed an increasing trend of research articles on VTE after arthroplasty. Publications with higher levels of evidence gained further popularity among researchers and orthopedic surgeons. Additionally, individualized VTE prevention and the development of new, safe, effective, and inexpensive oral agents would be emerging trends in the future.
在过去几十年中，髋或膝关节置换术后静脉血栓栓塞症（VTE）受到了越来越多的关注。然而，该领域尚无文献计量学报告。本研究旨在分析关节置换术后VTE的全球研究现状、热点及趋势。
从Web of Science核心合集数据库中检索1990年至2021年期间所有关于髋或膝关节置换术后VTE研究的文章。提取每篇文章的信息，包括引用次数、标题、作者、期刊、国家、机构、关键词和证据水平，进行文献计量学分析。
共检索到来自53个国家和603个机构的1245篇原创文章。美国贡献最多，有457篇文章，其次是英国和加拿大。加拿大的麦克马斯特大学是发表文章最多的机构。发表量和引用量最高的期刊分别是《关节置换术杂志》和《血栓与止血》。不同证据水平的文章引用次数中位数存在显著差异（ = 128.957，< 0.001）。从关键词分析和共被引参考文献聚类分析可以看出，研究热点从VTE诊断和肝素转向了Xa因子抑制剂（磺达肝癸钠、利伐沙班、阿哌沙班）和直接凝血酶抑制剂（达比加群酯、希美加群），最后转向了阿司匹林、危险因素研究。
本研究观察到关节置换术后VTE研究文章呈增加趋势。证据水平较高的出版物在研究人员和骨科医生中更受欢迎。此外，个性化的VTE预防以及新型、安全、有效且廉价口服药物的开发将是未来的新兴趋势。
