Rastogi Sanya, Meador Kimford J, Barr William B, Devinsky Orrin, Leeman-Markowski Beth A
Epilepsy and Cognition Laboratory, Veterans Affairs, New York Harbor Healthcare System, Research Service, New York, NY, United States.
College of Arts and Science, New York University, New York, NY, United States.
Front Neurol. 2022 Apr 8;13:855332. doi: 10.3389/fneur.2022.855332. eCollection 2022.
Studies of epilepsy patients provide insight into the neuroscience of human memory. Patients with remote memory deficits may learn new information but have difficulty recalling events from years past. The processes underlying remote memory impairment are unclear and likely result from the interaction of multiple factors, including hippocampal dysfunction. The hippocampus likely has a continued role in remote semantic and episodic memory storage over time, and patients with mesial temporal lobe epilepsy (TLE) are at particular risk for deficits. Studies have focused on lateralization of remote memory, often with greater impairment in left TLE, which may relate to verbal task demands. Remote memory testing is restricted by methodological limitations. As a result, deficits have been difficult to measure. This review of remote memory focuses on evidence for its underlying neurobiology, theoretical implications for hippocampal function, and methodological difficulties that complicate testing in epilepsy patients.
对癫痫患者的研究有助于深入了解人类记忆的神经科学。患有远期记忆缺陷的患者可能能够学习新信息，但回忆多年前的事件却有困难。远期记忆受损的潜在机制尚不清楚，可能是多种因素相互作用的结果，包括海马体功能障碍。随着时间的推移，海马体可能在远期语义记忆和情景记忆存储中持续发挥作用，而内侧颞叶癫痫（TLE）患者出现记忆缺陷的风险尤其高。研究主要集中在远期记忆的脑区定位，通常左颞叶癫痫患者的损伤更为严重，这可能与语言任务需求有关。远期记忆测试受到方法学限制。因此，缺陷难以测量。这篇关于远期记忆的综述重点关注其潜在神经生物学的证据、对海马体功能的理论意义，以及在癫痫患者测试中使情况复杂化的方法学困难。
