Chen Hao, Wang Yumin, Xie Zhiguo, Zhang Luyuan, Ge Yongsheng, Yu Jihai, Zhang Chuanhai, Jia Weidong, Ma Jinliang, Liu Wenbin
Department of Hepatic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Front Oncol. 2022 Apr 6;12:819960. doi: 10.3389/fonc.2022.819960. eCollection 2022.
This study aimed to evaluate the efficiency and safety of indocyanine green (ICG) fluorescence real-time imaging-guided technology in laparoscopic hepatectomy. A retrospective analysis of patients with primary liver cancer in the First Affiliated Hospital of USTC from January 2018 to October 2021, including 48 cases of fluorescence-guided laparoscopic hepatectomy (FGLH) and 60 cases of traditional laparoscopic hepatectomy (LH), was conducted. R0 resection rate, operation time, intraoperative blood loss, complications, hospital stay, and other intraoperative and postoperative indicators of the two groups were analyzed to determine the clinical feasibility and safety of ICG fluorescence real-time imaging-guided technology in laparoscopic hepatectomy. Related databases were searched for retrospective cohort studies and randomized controlled trials comparing FGLH with LH, studies were screened according to preset inclusion and exclusion criteria, literature quality was evaluated, and data were extracted. RevMan 5.3 software was used to conduct a meta-analysis on the extracted data. The results of our clinical data and meta-analysis showed that compared with LH, FGLH increased the R0 resection rate, shortened the operation time and postoperative hospital stay, and reduced blood loss and the occurrence of postoperative complications. Compared with LH, FGLH has a better application effect in laparoscopic hepatectomy, and it is worthy of promotion as it is safe and feasible.
本研究旨在评估吲哚菁绿（ICG）荧光实时成像引导技术在腹腔镜肝切除术中的有效性和安全性。对中国科学技术大学附属第一医院2018年1月至2021年10月期间的原发性肝癌患者进行回顾性分析，其中包括48例荧光引导腹腔镜肝切除术（FGLH）和60例传统腹腔镜肝切除术（LH）。分析两组的R0切除率、手术时间、术中出血量、并发症、住院时间等术中及术后指标，以确定ICG荧光实时成像引导技术在腹腔镜肝切除术中的临床可行性和安全性。检索相关数据库，查找比较FGLH与LH的回顾性队列研究和随机对照试验，根据预设的纳入和排除标准筛选研究，评估文献质量，并提取数据。使用RevMan 5.3软件对提取的数据进行Meta分析。我们的临床数据和Meta分析结果显示，与LH相比，FGLH提高了R0切除率，缩短了手术时间和术后住院时间，减少了出血量和术后并发症的发生。与LH相比，FGLH在腹腔镜肝切除术中具有更好的应用效果，因其安全可行，值得推广。
