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潜在药用植物提取物抗登革热和基孔肯雅病毒的抗病毒活性。

Antiviral Activity of Potential Medicinal Plant Extracts Against Dengue and Chikungunya Viruses.

机构信息

Dengue and Chikungunya Group, Indian Council of Medical Research (ICMR)-National Institute of Virology, Pune, India.

Department of Natural Product Chemistry, Indian Council of Medical Research (ICMR)-National Institute of Traditional Medicine, Belagavi, India.

出版信息

Front Cell Infect Microbiol. 2022 Apr 7;12:866452. doi: 10.3389/fcimb.2022.866452. eCollection 2022.

DOI:10.3389/fcimb.2022.866452
PMID:35463636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9021897/
Abstract

Dengue and chikungunya are two important mosquito-borne infections which are known to occur extensively in tropical and subtropical areas. Presently, there is no treatment for these viral diseases. antiviral screening of 25 extracts prepared from the plants of , , , , , , , and using different solvents and four purified compounds (anacardic acid, chloroquinone, glaucarubinone, and methyl gallate) were carried out for their anti-dengue virus (DENV) and anti-chikungunya virus (CHIKV) activities. Maximum nontoxic concentrations of the chloroform, methanol, ethyl acetate, petroleum ether, dichloromethane, and hydroalcoholic extracts of eight plants were used. The antiviral activity was assessed by focus-forming unit assay, quantitative real-time RT-PCR, and immunofluorescence assays. Extracts from , , , and showed both anti-DENV and CHIKV activity while extract from showed only anti-DENV activity. Among the purified compounds, anacardic acid, chloroquinone and methyl gallate showed anti-dengue activity while only methyl gallate had anti-chikungunya activity. The present study had identified the plant extracts with anti-dengue and anti-chikungunya activities, and these extracts can be further characterized for finding effective phytopharmaceutical drugs against dengue and chikungunya.

摘要

登革热和基孔肯雅热是两种重要的蚊媒传染病，已知广泛存在于热带和亚热带地区。目前，这些病毒性疾病尚无治疗方法。我们对 、 、 、 、 、 、 等植物的 25 种提取物进行了抗病毒筛选，这些提取物使用了不同的溶剂和 4 种纯化化合物（没食子酸、氯喹酮、黄烷酮和甲基没食子酸），以评估它们对登革热病毒（DENV）和基孔肯雅热病毒（CHIKV）的抗病毒活性。使用最大无毒浓度的氯仿、甲醇、乙酸乙酯、石油醚、二氯甲烷和水醇提取物进行了研究。采用噬斑形成单位测定法、实时定量 RT-PCR 和免疫荧光法评估抗病毒活性。来自 、 、 、 的提取物均表现出抗 DENV 和 CHIKV 活性，而来自 的提取物仅表现出抗 DENV 活性。在纯化化合物中，没食子酸、氯喹酮和甲基没食子酸表现出抗登革热活性，而只有甲基没食子酸具有抗基孔肯雅热活性。本研究鉴定了具有抗登革热和抗基孔肯雅热活性的植物提取物，这些提取物可以进一步进行特征分析，以寻找有效的植物药物来治疗登革热和基孔肯雅热。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01d8/9021897/29816b593982/fcimb-12-866452-g013.jpg
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