Jinhua Municipal Central Hospital (Affiliated Jinhua Hospital, School of Medicine, Zhejiang University), Jinhua 321000, Zhejiang, China.
J Healthc Eng. 2022 Apr 13;2022:6412740. doi: 10.1155/2022/6412740. eCollection 2022.
This study aimed to investigate the correlation between the urine protein/creatinine ratio (PCR) and 24 h urine total protein quantity (24hUTP) in morning and random urine and its prediction equation. Rituximab (RTX), a monoclonal antibody that acts on the B cell epitope CD20, has been used in the renal field since 2005 and has become a hot topic in the clinical treatment of many glomerulonephritis diseases. Apart from focusing on the safety and efficacy of RTX in clinical treatment, some scholars are still working on the mechanism of its action in the treatment of renal diseases, trying to find its specific targets in renal tissues. . There was no significant difference between morning urine PCR, random urine PCR, and 24hUTP (=0.81); there was a significant positive correlation between morning urine PCR and 24hUTP ( = 0.90, < 0.01) and between random urine PCR and 24hUTP ( = 0.95, < 0.01), and the correlation between random urine PCR and 24hUTP was higher than that between morning urine PCR and 24hUTP. The results of the ROC curve analysis showed that the correlation between morning urine PCR, random urine PCR, and 24hUTP was higher than that between morning urine PCR and 24hUTP in different groups. The optimal threshold values for random urine PCR to predict 2.4hUTP were 0.56 g/g (sensitivity 93.5%; specificity 75.4%), 1.11 g/g (sensitivity 98.3%; specificity 92.4%), and 3.43 g/g (sensitivity 87.9%; specificity 89.9%), respectively. The equations for predicting 24hUTP by morning urine PCR and random urine PCR were as follows: (1) 24hUTP(g) = 0.793 + 0.793 × morning urine PCR + 0.124 × total cholesterol - 0.177 × Alb (coefficient of determination = 0.87); (2) 24hUTP(g) = 0.369 + 0.856 × random urine PCR + 0.132 × total cholesterol - 0.092 × Alb (coefficient of determination = 0.92); the prediction equation of random urine was more accurate than that of morning urine. The correlation was not affected by gender, age, 24 h urine volume, etiology, eGFR, Alb, or total cholesterol level, and the correlation between random urine PCR and 24hUTP was higher than that of morning urine PCR. CR prediction equation was used instead of the 24hUTP test.
本研究旨在探讨晨尿、随机尿中尿蛋白/肌酐比（PCR）与 24 小时尿总蛋白量（24hUTP）的相关性及其预测方程。利妥昔单抗（RTX）是一种作用于 B 细胞表位 CD20 的单克隆抗体，自 2005 年以来已在肾脏领域应用，并成为许多肾小球肾炎疾病临床治疗的热点。除了关注 RTX 在临床治疗中的安全性和有效性外，一些学者仍在研究其在肾脏疾病治疗中的作用机制，试图在肾脏组织中找到其特定靶点。. 晨尿 PCR、随机尿 PCR 和 24hUTP 之间无显著差异（=0.81）；晨尿 PCR 与 24hUTP 之间呈显著正相关（=0.90， < 0.01），随机尿 PCR 与 24hUTP 之间呈显著正相关（=0.95， < 0.01），随机尿 PCR 与 24hUTP 之间的相关性高于晨尿 PCR 与 24hUTP 之间的相关性。ROC 曲线分析结果表明，在不同分组中，晨尿 PCR、随机尿 PCR 和 24hUTP 之间的相关性均高于晨尿 PCR 与 24hUTP 之间的相关性。随机尿 PCR 预测 2.4hUTP 的最佳截断值分别为 0.56g/g（灵敏度 93.5%，特异性 75.4%）、1.11g/g（灵敏度 98.3%，特异性 92.4%）和 3.43g/g（灵敏度 87.9%，特异性 89.9%）。晨尿 PCR 和随机尿 PCR 预测 24hUTP 的方程如下：（1）24hUTP（g）=0.793+0.793×晨尿 PCR+0.124×总胆固醇-0.177×Alb（决定系数 = 0.87）；（2）24hUTP（g）=0.369+0.856×随机尿 PCR+0.132×总胆固醇-0.092×Alb（决定系数 = 0.92）；随机尿的预测方程比晨尿更准确。相关性不受性别、年龄、24 小时尿量、病因、eGFR、Alb 或总胆固醇水平的影响，且随机尿 PCR 与 24hUTP 之间的相关性高于晨尿 PCR。用 CR 预测方程代替 24hUTP 检测。
