School of Pharmacy and Food Science, Zhuhai College of Science and Technology, Jinwan 519041, China.
J Healthc Eng. 2022 Apr 15;2022:7282453. doi: 10.1155/2022/7282453. eCollection 2022.
is a natural drugs which has many pharmacological effects such as antitumor and enhanced immune activity. This paper studies the therapeutic effect of fruiting body (CVFB) on streptozotocin (STZ)-induced Institute of Cancer Research (ICR) diabetic mice, the STZ solution was administered intraperitoneally at a dose of 150 mg/kg after fasting the mice, and ICR mice with fasting blood glucose >16.7 mmol/l were selected for research. Metformin was the positive control, and the dose of CVFB powder (1000 mg/kg, 2000 mg/kg, and 4000 mg/kg) for 28 consecutive days by gavage. The serum and liver of mice were collected for relevant index content testing. The results showed that CVFB can control or reduce the fasting blood glucose of mice and accelerate the rate of glucose metabolism, can reduce the levels of total cholesterol (T-CHO), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) in mice, and regulate the abnormal symptoms of blood lipid metabolism commonly found in diabetes. It can increase the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) antioxidant enzymes and enhance the ability of antioxidative stress in diabetic mice. In the H&E staining and apoptosis experiments of pancreatic tissue, CVFB can greatly reduce the inflammatory factors present in islets, increase the islet cells, and reduce the apoptotic rate caused by diabetes. All data confirmed the therapeutic effect of CVFB on diabetic ICR mice. The present study provides a scientific basis for the development of drugs for the prevention and treatment of diabetes, it is of great significance to the in-depth study of
是一种天然药物，具有多种药理作用，如抗肿瘤和增强免疫活性。本文研究了子实体（CVFB）对链脲佐菌素（STZ）诱导的癌症研究所（ICR）糖尿病小鼠的治疗作用，STZ 溶液在禁食后通过腹腔内注射给药，剂量为 150mg/kg，选择空腹血糖>16.7mmol/l的 ICR 小鼠进行研究。二甲双胍为阳性对照，CVFB 粉末（1000mg/kg、2000mg/kg 和 4000mg/kg）连续灌胃 28 天。收集小鼠血清和肝脏进行相关指标含量检测。结果表明，CVFB 能控制或降低小鼠空腹血糖，加速葡萄糖代谢率，降低小鼠总胆固醇（T-CHO）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）水平，调节糖尿病常见的血脂代谢异常症状。能提高超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）抗氧化酶的活性，增强糖尿病小鼠抗氧化应激能力。在胰岛组织的 H&E 染色和细胞凋亡实验中，CVFB 能大大减少胰岛内存在的炎症因子，增加胰岛细胞，降低糖尿病引起的细胞凋亡率。所有数据均证实了 CVFB 对糖尿病 ICR 小鼠的治疗作用。本研究为预防和治疗糖尿病药物的开发提供了科学依据，对深入研究具有重要意义。
