Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
J Healthc Eng. 2022 Apr 13;2022:1509407. doi: 10.1155/2022/1509407. eCollection 2022.
For investigating an influence on butylphthalide sodium chloride injection combined with edaravone dexborneol on neurological function and serum inflammatory factor levels in sufferers having acute ischemic stroke, 120 sufferers having acute ischemic stroke from September 2020 to September 2021 are chosen for the study subjects. In line with the diverse therapies, they took part in a control group and the study group, with 60 examples in each group. The control group is treated with edaravone dexborneol, and the study group is treated with butylphthalide sodium chloride injection, based on the control group. The posttreatment curative efficacy on the two groups is recorded, and treatment of both the two groups is compared. Before and after neurological function indexes (NIHSS and mRS), inflammatory factor indexes (IL-6, CRP, and TNF-), life quality index (Barthel index), hemorheological indexes (plasma-specific viscosity), and neurological levels of NSE are logged and contrasted between the two groups of adverse reactions during therapy. Postcure, the overall response rate and Barthel index of the study group obviously overtop those of the control group ( < 0.05). IL-6, CRP, TNF-, NSE, plasma specific viscosity, and NIHSS and mRS scores obviously hypodown those of the control group ( < 0.05), and untoward effects on the two groups during curing are lower, and the discrepancy is not obvious( > 0.05). Butylphthalide sodium chloride injection combined with edaravone dexborneol can enhance curative efficacy on sufferers having acute ischemic stroke, improve neurological function, blood rheology, and quality of life, and decrease the secretion of cytokine, having a better effect and high medication safety.
为了研究丁苯酞氯化钠注射液联合依达拉奉右莰醇对急性缺血性脑卒中患者神经功能及血清炎症因子水平的影响,选取 2020 年 9 月至 2021 年 9 月收治的 120 例急性缺血性脑卒中患者作为研究对象。根据不同的治疗方法,他们分为对照组和观察组,每组 60 例。对照组给予依达拉奉右莰醇治疗,观察组在对照组的基础上给予丁苯酞氯化钠注射液治疗。记录两组患者的治疗后疗效,并进行两组治疗效果的比较。治疗前后记录两组患者的神经功能指标(NIHSS 和 mRS)、炎症因子指标(IL-6、CRP、TNF-)、生活质量指标(Barthel 指数)、血液流变学指标(血浆比粘度)和 NSE 神经水平,并比较两组不良反应。治疗后,观察组的总有效率和 Barthel 指数明显高于对照组(<0.05)。IL-6、CRP、TNF-、NSE、血浆比粘度、NIHSS 和 mRS 评分明显低于对照组(<0.05),两组治疗过程中的不良反应较低,差异不明显(>0.05)。丁苯酞氯化钠注射液联合依达拉奉右莰醇治疗急性缺血性脑卒中患者,能提高疗效,改善神经功能、血液流变学和生活质量,降低细胞因子的分泌,效果较好,用药安全性较高。