Delfino Enrica, Peano Luca, Wetzl Roberto Giorgio, Giannì Maria Lorella, Netto Roberta, Consales Alessandra, Bettinelli Maria Enrica, Morniroli Daniela, Vielmi Francesca, Mosca Fabio, Montagnani Luca
Department of Anesthesia, Intensive Care, and Out-Hospital Emergency, Ospedale Regionale della Valle d'Aosta, Aosta, Italy.
Department of Pediatrics, Ospedale Regionale della Valle d'Aosta, Aosta, Italy.
Front Pediatr. 2022 Apr 7;10:871595. doi: 10.3389/fped.2022.871595. eCollection 2022.
To investigate the association between neonatal weight loss and persistence of exclusive breastfeeding up to 6 months.
An observational cohort study in the setting of a Baby Friendly Hospital, enrolling 1,260 healthy term dyads. Neonatal percentage of weight loss was collected between 48 and 72 h from birth. Using a questionnaire, all mothers were asked on the phone what the infant's mode of feeding at 10 days, 42 days and 6 months (≥183 days) from birth were. The persistence of exclusive breastfeeding up to 6 months and the occurrence of each event that led to the interruption of exclusive breastfeeding were verified through a logistic analysis that included 40 confounders.
Infants with a weight loss ≥7% were exclusively breastfed at 6 months in a significantly lower percentage of cases than infants with a weight loss <7% (95% CI 0.563 to 0.734, < 0.001). Weight loss ≥7% significantly increases the occurrence of either sporadic integration with formula milk (95% CI 0.589 to 0.836, < 0.001), complementary feeding (95% CI 0.460 to 0.713, < 0.001), exclusive formula feeding (95% CI 0.587 to 0.967, < 0.001) or weaning (95% CI 0.692 to 0.912, = 0.02) through the first 6 months of life.
With the limitations of a single-center study, a weight loss ≥7% in the first 72 h after birth appears to be a predictor of an early interruption of exclusive breastfeeding before the recommended 6 months in healthy term exclusively breastfed newborns.
研究新生儿体重减轻与纯母乳喂养至6个月的持续情况之间的关联。
在一家爱婴医院进行的一项观察性队列研究，纳入1260对健康足月儿母婴。在出生后48至72小时收集新生儿体重减轻的百分比。通过电话问卷询问所有母亲婴儿在出生后10天、42天和6个月（≥183天）的喂养方式。通过包含40个混杂因素的逻辑分析，验证纯母乳喂养至6个月的持续情况以及导致纯母乳喂养中断的每个事件的发生情况。
体重减轻≥7%的婴儿在6个月时纯母乳喂养的比例明显低于体重减轻<7%的婴儿（95%置信区间0.563至0.734，P<0.001）。体重减轻≥7%显著增加了在出生后头6个月内与配方奶间歇性混合喂养（95%置信区间0.589至0.836，P<0.001）、添加辅食（95%置信区间0.460至0.713，P<0.001）、完全配方奶喂养（95%置信区间0.587至0.967，P<0.001）或断奶（95%置信区间0.692至0.912，P = 0.02）的发生率。
尽管存在单中心研究的局限性，但出生后72小时内体重减轻≥7%似乎是健康足月儿纯母乳喂养新生儿在推荐的6个月前纯母乳喂养提前中断的一个预测因素。
