Buonsenso Danilo, Graffeo Rosalia, Pata Davide, Valentini Piero, Palumbo Carla, Masucci Luca, Ruggiero Antonio, Attinà Giorgio, Onori Manuela, Lancella Laura, Lucignano Barbara, Giuseppe Martina Di, Bernaschi Paola, Cursi Laura
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Front Pediatr. 2022 Apr 7;10:783098. doi: 10.3389/fped.2022.783098. eCollection 2022.
While there are numerous studies regarding infection (CDI) in adults, literature on the pediatric population is scarce. Therefore, we performed a 5-year retrospective study between January 2014 and December 2018 in two referral centers in Rome, Italy. There were 359 patients tested for CDI who were enrolled: 87 resulted in positive and 272 in negative. CDI children had a higher number of previous-day hospital admissions ( = 0.024), hospitalizations ( = 0.001), and total hospital admissions ( = 0.008). Chronic comorbidities were more frequent in the CDI group (66.7% vs. 33.3%). Previous use of proton pump inhibitors and antibiotics was associated with CDI ( < 0.001). Among the antibiotics, only fluoroquinolones were significantly associated with CDI. Also, CDI children were more frequently exposed to antibiotics during the episode of hospitalization when children were tested. Our study provides an updated clinical and epidemiological analysis of children with CDI compared with a control group of children who tested negative. Further prospective studies could better define risk factors and preventive methods.
虽然有许多关于成人艰难梭菌感染（CDI）的研究，但关于儿科人群的文献却很少。因此，我们于2014年1月至2018年12月在意大利罗马的两个转诊中心进行了一项为期5年的回顾性研究。共有359名接受CDI检测的患者入组：87例结果为阳性，272例为阴性。CDI患儿前一天的住院次数（P = 0.024）、住院天数（P = 0.001）和总住院次数（P = 0.008）更多。慢性合并症在CDI组中更为常见（66.7%对33.3%）。既往使用质子泵抑制剂和抗生素与CDI相关（P < 0.001）。在抗生素中，只有氟喹诺酮类与CDI显著相关。此外，在进行检测的患儿住院期间，CDI患儿更频繁地接触抗生素。与检测结果为阴性的儿童对照组相比，我们的研究提供了对CDI患儿的最新临床和流行病学分析。进一步的前瞻性研究可以更好地确定危险因素和预防方法。
