[甲苯咪唑在古巴某些蠕虫病病例中的首次临床治疗试验]
[1st clinical therapeutic trial of mebendazole in some cases of helmenthiasis in Cuba].
作者信息
Otero Domínguez R, Galvez Oviedo M, Estevez Cazallas B
出版信息
Rev Cubana Med Trop. 1977 Jan-Apr;29(1):13-6.
Due to the difficulties faced in the etiologic approach of trichuriasis as a result of the intolerance, reduced efficacy and toxicity of some drugs a clinical-therapeutic trial of mebendazole was started in 5-64 year-old patients with some form of helmynthiasis as trichuriasis, enterobiasis or necatoriasis. Coproparasitological examinations carried out 15, 30 and 45 days after the ingestion of the drug depicted an excellent cure rate (98% in trichuriasis; 100% in enterobiasis; and 85% in necatoriasis). Very few side-effects were found. This is the first clinical-therapeutic trial of mebendazole in parasitic diseases in our country, and it can be affirmed that results have been very positive and also that they are similar to those obtained by foreign authors.
由于某些药物的不耐受性、疗效降低和毒性，导致在治疗鞭虫病的病因学方法上存在困难，因此于1975年开始了一项针对5至64岁患有某种形式蠕虫病（如鞭虫病、蛲虫病或钩虫病）患者的甲苯咪唑临床治疗试验。在服药后15、30和45天进行的粪便寄生虫学检查显示治愈率极佳（鞭虫病为98%；蛲虫病为100%；钩虫病为85%）。发现的副作用极少。这是我国首次针对寄生虫病进行的甲苯咪唑临床治疗试验，可以肯定的是，结果非常积极，而且与国外作者获得的结果相似。
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