Departamento de Oncología Médica, San Carlos University Hospital, IdISSC, Madrid, Madrid, 28040, Spain.
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
F1000Res. 2022 Feb 16;11:196. doi: 10.12688/f1000research.109221.2. eCollection 2022.
Human bocavirus (HBoV) is a viral pathogen from the genus (family , subfamily ) discovered in 2005. Most of available literature is about HBoV in children and adults with hematological malignancies and in otherwise healthy children with respiratory infections. Information regarding infection in the adult population with solid tumors is scarce. We report the case of a 51-year-old male with metastatic castration resistant prostate cancer undergoing chemotherapy treatment who presented with fever, dyspnea, dry cough, and pleuritic pain. Imaging techniques showed signs of congestive heart failure. Symptoms, laboratory tests and echocardiography revealed a more probable infectious etiology. Antibiotic therapy was started. A polymerase chain reaction (PCR) test of nasopharyngeal exudate for respiratory viruses was positive for HBoV. The rest of the microbiological tests were negative. Bronchoalveolar lavage (BAL) was performed. Bacterial culture of BAL was negative while respiratory virus PCR confirmed positivity for HBoV. Antibiotic therapy was discontinued. The patient gradually recovered. Emerging infectious diseases are a notorious threat for immunocompromised populations such as solid tumor patients. This case is unique because to our knowledge this is the first case report article of HBoV in a solid tumor patient and because imaging techniques exhibited signs of congestive heart failure that did not correlate with the rest of the tests. It shows that unusual pathogens should be considered when managing serious clinical complications with uncommon presentations in cancer patients. Notable diagnostic efforts should be made to reach a diagnosis in these cases.
人博卡病毒（HBoV）是一种病毒病原体，属于 （科，亚科），于 2005 年发现。大多数现有文献都是关于血液系统恶性肿瘤患儿和其他健康儿童呼吸道感染中的 HBoV。关于实体瘤成年人群中感染的信息很少。我们报告了一例 51 岁男性患有转移性去势抵抗性前列腺癌，正在接受化疗治疗，他出现发热、呼吸困难、干咳和胸膜炎性疼痛。影像学技术显示充血性心力衰竭的迹象。症状、实验室检查和超声心动图显示更可能的感染病因。开始使用抗生素治疗。鼻咽分泌物呼吸道病毒聚合酶链反应（PCR）检测 HBoV 呈阳性。其余微生物学检查均为阴性。进行了支气管肺泡灌洗（BAL）。BAL 的细菌培养为阴性，而呼吸道病毒 PCR 则证实 HBoV 呈阳性。停止使用抗生素。患者逐渐康复。新发传染病是免疫功能低下人群（如实体瘤患者）的一个严重威胁。这个病例很独特，因为据我们所知，这是首例 HBoV 在实体瘤患者中的病例报告文章，而且影像学技术显示出充血性心力衰竭的迹象，但与其他检查结果不相关。这表明，在管理癌症患者出现不常见表现的严重临床并发症时，应考虑不常见的病原体。在这些情况下，应做出显著的诊断努力以明确诊断。
