Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Center, Health Technology Institute, University of Medical Sciences, Kermanshah, Iran.
Front Immunol. 2022 Apr 8;13:865782. doi: 10.3389/fimmu.2022.865782. eCollection 2022.
Type 1 diabetes (T1D) is a chronic disorder characterized by immune-mediated destruction of pancreatic insulin-producing β-cells. The primary treatment for T1D is multiple daily insulin injections to control blood sugar levels. Cell-free delivery packets with therapeutic properties, extracellular vesicles (EVs), mainly from stem cells, have recently gained considerable attention for disease treatments. EVs provide a great potential to treat T1D ascribed to their regenerative, anti-inflammatory, and immunomodulatory effects. Here, we summarize the latest EV applications for T1D treatment and highlight opportunities for further investigation.
1 型糖尿病（T1D）是一种慢性疾病，其特征是免疫介导的胰腺胰岛素产生β细胞破坏。T1D 的主要治疗方法是多次每日胰岛素注射以控制血糖水平。无细胞递药包具有治疗特性，细胞外囊泡（EVs）主要来源于干细胞，最近因其再生、抗炎和免疫调节作用而受到广泛关注。在这里，我们总结了 EV 在 T1D 治疗中的最新应用，并强调了进一步研究的机会。
