El Sayed Fouad, Kabbani Mariam
Dermatology, Lebanese University Faculty of Medicine, Beirut, LBN.
Cureus. 2022 Mar 12;14(3):e23090. doi: 10.7759/cureus.23090. eCollection 2022 Mar.
Psoriasis is a chronic inflammatory skin disease whose treatment arsenal is expanding by the day. However, when comorbidities coexist, therapy can be challenging. We report a case of a 55-year-old female with steroid-dependent myasthenia gravis who presented with a severe form of chronic plaque psoriasis. After the failure of topical corticosteroids and phototherapy, the patient was started on ixekizumab. This anti-IL-17 antibody led not only to the clearance of the psoriatic lesions but also to the remission of the myasthenic symptoms. While on this medication, the patient was able to taper down and discontinue the oral corticosteroids. The remission of the symptoms of myasthenia gravis during this treatment supports the role of IL-17 cytokines in the pathogenesis of this disease and adds it as a management option in steroid-dependent cases.
银屑病是一种慢性炎症性皮肤病，其治疗手段日益丰富。然而，当合并其他疾病时，治疗可能具有挑战性。我们报告一例55岁女性，患有类固醇依赖型重症肌无力，同时伴有严重的慢性斑块状银屑病。在局部使用皮质类固醇和光疗失败后，患者开始使用司库奇尤单抗治疗。这种抗白细胞介素-17抗体不仅使银屑病皮损消退，还使重症肌无力症状得到缓解。在使用这种药物期间，患者能够逐渐减少并停用口服皮质类固醇。在此治疗过程中重症肌无力症状的缓解支持了白细胞介素-17细胞因子在该疾病发病机制中的作用，并将其作为类固醇依赖型病例的一种治疗选择。
