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撒哈拉以南非洲地区脾肾分流术后获得性肝脑变性:一例报告及文献简要综述

Acquired Hepatocerebral Degeneration After a Splenorenal Shunt in the Sub-Saharan Africa Context: A Case Report and Brief Review of Literature.

作者信息

Mohammed Abdu, Bane Abate, Mengistu Getahun, Ayalew Fekadu, Seid Amir Sultan

机构信息

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Adera Medical Center, Addis Ababa, ETH.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Addis Ababa University, Addis Ababa, ETH.

出版信息

Cureus. 2022 Mar 11;14(3):e23064. doi: 10.7759/cureus.23064. eCollection 2022 Mar.

Abstract

Acquired hepatocerebral degeneration (AHD) is a neurologic syndrome caused by liver dysfunction and long-standing portosystemic shunting. The pathogenesis of the condition is predominantly considered to be related to the deposition of manganese in parts of the brain due to shunting. We report a case of a 25-year-old male who underwent splenectomy and splenorenal shunt for recurrent upper GI bleeding (UGIB) due to esophageal varices caused by non-cirrhotic portal hypertension (NCPH). He presented with bradykinesia, hypophonia, gait instability, and rigidity of the lower extremities 18 months after the procedure was done.

摘要

获得性肝脑变性(AHD)是一种由肝功能障碍和长期门体分流引起的神经综合征。该病的发病机制主要被认为与分流导致锰在脑内部分区域沉积有关。我们报告一例25岁男性病例,该患者因非肝硬化门静脉高压(NCPH)导致食管静脉曲张,因反复上消化道出血(UGIB)接受了脾切除术和脾肾分流术。术后18个月,他出现了运动迟缓、声音低微、步态不稳和下肢僵硬的症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a17b/9001859/664afc87a059/cureus-0014-00000023064-i01.jpg

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