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印度西部地区一家三级医疗医院对路德维希咽峡炎的管理

Management of Ludwig's Angina at a Tertiary Care Hospital in Western Region of India.

作者信息

Parmar Bhagirath D, Joshi Krupal J, Modi Ankur D, Dave Gavendra P, Desai Raji S

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, C U Shah Medical College and Hospital, Surendranagar, IND.

Department of Community and Family Medicine, All India Institute of Medical Sciences, Rajkot, IND.

出版信息

Cureus. 2022 Mar 19;14(3):e23311. doi: 10.7759/cureus.23311. eCollection 2022 Mar.

Abstract

Introduction Ludwig's angina is cellulitis of submandibular space, submental space, and sublingual space. The main causative factors include dental infections (dental caries with atypical periodontitis, pericoronitis, and dental procedures). Other predisposing conditions include poor dental hygiene, dental caries, malnutrition, diabetes mellitus, AIDS, and various other immunocompromised states. It presents as an acute onset and spreads very rapidly causing bilateral diffuse neck swelling, edema of floor of mouth, pain, fever, trismus, foul-smelling pus discharge, difficulty in swallowing, airway edema, and tongue displacement creating a compromised airway with stridor. So it requires early diagnosis and aggressive management. Material and methods Clinical data of all patients with clinical diagnosis of Ludwig's angina managed at the Department of Otorhinolaryngology-Head and Neck Surgery, Sir Takhatsinhji (T) General Hospital and Government Medical College, Bhavnagar, India, from 2015 to 2019 were analyzed retrospectively in this study. Result Over the review period, 30 cases were diagnosed as Ludwig's angina, out of which 12 (40%) were males and 18 (60%) were females; male to female ratio was 1:1.5. The age of the patients ranged from six months to 64 years, with a mean age of 38.86 years. Fever, neck swelling, and neck pain were present in all patients. In 16 patients, incision and drainage were done under general anesthesia while the rest five patients required only local anesthesia. In six patients (20%), for maintenance of airway, tracheostomy was required. The most common complication was necrotizing fasciitis and death followed by septicemia. Mortality was observed in three patients (10%) in this study. Conclusion Despite improved outcomes compare to pre-antibiotic era, Ludwig's angina still remains a potentially life-threatening disease in ENT at present. Dental caries, uncontrolled diabetes mellitus, and malnutrition are commonly associated conditions. With early diagnosis, close airway observation, aggressive intravenous antibiotic treatment, and timely surgical intervention, morbidity, and mortality can be reduced.

摘要

引言 路德维希咽峡炎是指下颌下间隙、颏下间隙及舌下间隙的蜂窝织炎。主要致病因素包括牙齿感染(伴有非典型牙周炎、冠周炎的龋齿及牙科手术)。其他易感因素包括口腔卫生差、龋齿、营养不良、糖尿病、艾滋病及其他各种免疫功能低下状态。其表现为急性起病,传播迅速,导致双侧弥漫性颈部肿胀、口底水肿、疼痛、发热、牙关紧闭、恶臭脓性分泌物、吞咽困难、气道水肿及舌移位,进而造成气道受损并伴有喘鸣。因此,需要早期诊断及积极治疗。

材料与方法 本研究回顾性分析了2015年至2019年期间在印度巴夫纳格尔萨赫塔辛吉(T)综合医院及政府医学院耳鼻喉头颈外科接受治疗的所有临床诊断为路德维希咽峡炎患者的临床资料。

结果 在回顾期间,30例患者被诊断为路德维希咽峡炎,其中男性12例(40%),女性18例(60%);男女比例为1:1.5。患者年龄从6个月至64岁不等,平均年龄为38.86岁。所有患者均出现发热、颈部肿胀及颈部疼痛。16例患者在全身麻醉下进行切开引流,其余5例患者仅需局部麻醉。6例患者(20%)需要行气管切开术以维持气道通畅。最常见的并发症是坏死性筋膜炎和败血症,其次是死亡。本研究中有3例患者(10%)死亡。

结论 尽管与抗生素使用前的时代相比,治疗效果有所改善,但目前路德维希咽峡炎在耳鼻喉科仍是一种潜在的危及生命的疾病。龋齿、未控制的糖尿病及营养不良是常见的相关病症。通过早期诊断、密切观察气道、积极静脉使用抗生素治疗及及时的手术干预,可降低发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9015074/3b8b8de408f4/cureus-0014-00000023311-i01.jpg

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