Department of Pharmacology & Toxicology, Laboratory of Epigenetics & Diseases, National Institute of Pharmaceutical Education & Research, Sector-67, S.A.S. Nagar, Punjab, 160062, India.
Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, 14000, India.
Nanomedicine (Lond). 2022 Apr;17(9):607-625. doi: 10.2217/nnm-2021-0401. Epub 2022 Apr 25.
To evaluate whether selenium nanoparticles (SeNPs) can stimulate bone formation and inhibit the bone loss involved in hyperglycemia-induced osteoporosis. Rat osteoblastic UMR-106 cells were used for studies and female Sprague-Dawley rats were used for type 2 diabetes-associated osteoporosis study. studies show that SeNPs promote osteoblast differentiation via modulating alkaline phosphatase (ALP) activity, and promoting calcium nodule formation and collagen content. The authors also provide evidence regarding the involvement of the BMP-2/MAPKs/β-catenin pathway in preventing diabetic osteoporosis. Further, and studies suggested that SeNPs can preserve mechanical and microstructural properties of bone. To the best of our knowledge, this study provides the first evidence regarding the therapeutic benefits of SeNPs in preventing diabetes-associated bone fragility.
为了评估硒纳米粒子（SeNPs）是否可以刺激骨形成并抑制高血糖诱导的骨质疏松症相关的骨质流失。研究使用大鼠成骨细胞 UMR-106 细胞和雌性 Sprague-Dawley 大鼠进行 2 型糖尿病相关骨质疏松症研究。研究表明，SeNPs 通过调节碱性磷酸酶（ALP）活性，促进钙结节形成和胶原含量，从而促进成骨细胞分化。作者还提供了有关 BMP-2/MAPKs/β-连环蛋白通路参与预防糖尿病性骨质疏松症的证据。此外，和 研究表明，SeNPs 可以保持骨的机械和微观结构特性。据我们所知，这项研究首次提供了 SeNPs 在预防糖尿病相关骨脆弱方面的治疗益处的证据。
