MRC Cognition and Brain Sciences Unit, 15 Chaucer Rd, Cambridge CB2 7EF, UK.
Institute of Cognitive Neuroscience, UCL, Alexandra House, 17-19 Queen Square, London WC1N 3AZ, UK.
Trends Cogn Sci. 2022 Jun;26(6):499-513. doi: 10.1016/j.tics.2022.03.004. Epub 2022 Apr 21.
An increasing recognition that brain and body are dynamically coupled has enriched our scientific understanding of mental health conditions. Peripheral signals interact centrally to influence how we think and feel, generating our sense of the internal condition of the body, a process known as interoception. Disruptions to this interoceptive system may contribute to clinical conditions, including anxiety, depression, and psychosis. After reviewing the nature of interoceptive disturbances in mental health conditions, this review focuses on interoceptive pathways of existing and putative mental health treatments. Emerging clinical interventions may target novel peripheral treatment mechanisms. Future treatment development requires forward- and back-translation to uncover and target specific interoceptive processes in mental health to elucidate their efficacy relative to interventions targeting other factors.
人们越来越认识到，大脑和身体是动态耦合的，这丰富了我们对心理健康状况的科学理解。外周信号在中枢相互作用，影响我们的思维和感觉方式，从而产生我们对身体内部状况的感知，这个过程被称为内感受。这种内感受系统的紊乱可能导致包括焦虑、抑郁和精神病在内的临床病症。在回顾了心理健康状况下内感受紊乱的性质之后，本综述重点关注现有和潜在的心理健康治疗方法的内感受途径。新兴的临床干预措施可能针对新的外周治疗机制。未来的治疗发展需要向前和向后翻译，以揭示和针对心理健康中的特定内感受过程，从而阐明它们相对于针对其他因素的干预措施的疗效。
