Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Jl. WR. Supratman, Universitas Bengkulu, Kandang Limun, Kota Bengkulu, Indonesia.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jl. WR. Supratman, Universitas Bengkulu, Kandang Limun, Kota Bengkulu, Indonesia.
Inflammopharmacology. 2022 Dec;30(6):2139-2144. doi: 10.1007/s10787-022-00982-4. Epub 2022 Apr 25.
Gastroprotective is an effect caused by the compounds that have the capability of protecting the gastric mucosa. Peperomia pellucida L. plants contain alkaloids, flavonoids, saponins, tannins, and terpenoids, while Pachyrhizus erosus L. contains flavonoids, alkaloids, tannins, and saponins. Peperomia pellucida L. reportedly contains dillapiole compounds with a gastroprotective effect. Moreover, its isolation result from Pachyrhizus erosus L. indicates the presence of dulcitol, gentisic acid, and formononetin, which has antioxidant activity. This study aims to determine the gastroprotective effect of the combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract on rats with gastric ulcer models by looking at the ulcer index, percentage of inhibition, and histopathology. The research method used in this study was by making a combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract. The combined extract was then given to five treatment groups. Group I as a negative control, group II as a positive control was given sucralfate, groups III, IV, and V were given a combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract of 100, 200, and 400 mg/kg BW. The treatment was given orally for 14 days, after 1 h of treatment on the 14th day, 96% ethanol induction was given orally at a dose of 5 mg/kg BW. The animal dissection was performed 24 h after the induction. The results from observations showed an increase in body weight before and after the treatment. The ulcer index produced by negative control, positive control in the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.42; 2.04; and 1.07. This study showed that the combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract has a gastroprotective effect.
胃保护作用是指具有保护胃黏膜能力的化合物所产生的效果。蓬佩兰植物含有生物碱、类黄酮、皂苷、单宁和萜类化合物，而土瓜则含有类黄酮、生物碱、单宁和皂苷。蓬佩兰据称含有胃保护作用的大蒜素化合物。此外，从土瓜中分离出来的物质表明存在具有抗氧化活性的卫矛醇、龙胆酸和芒柄花素。本研究旨在通过观察溃疡指数、抑制率和组织病理学，确定蓬佩兰和土瓜组合提取物对胃溃疡模型大鼠的胃保护作用。本研究采用的方法是制作蓬佩兰和土瓜组合提取物。然后将组合提取物给予五组治疗组。第 I 组作为阴性对照组，第 II 组作为阳性对照组给予蔗糖铁，第 III、IV 和 V 组分别给予 100、200 和 400mg/kg BW 的蓬佩兰和土瓜组合提取物。治疗方法为口服 14 天，第 14 天治疗 1 小时后，口服给予 96%乙醇，剂量为 5mg/kg BW。诱导后 24 小时进行动物解剖。观察结果显示，治疗前后体重均有增加。阴性对照、阳性对照（剂量为 100、200 和 400）的溃疡指数分别为 4.18；2.98；2.42；2.04；和 1.07。本研究表明，蓬佩兰和土瓜组合提取物具有胃保护作用。
