Fujie M, Ichikawa S, Kogure M, Hatakeyama K, Kawajiri S, Murata K
Jpn Circ J. 1986 Nov;50(11):1174-80. doi: 10.1253/jcj.50.1174.
The effect of ketanserin (KET), a specific 5-hydroxytryptamine2 (5-HT2) receptor blockade, on pressor response to vasoactive substances was examined in rats with one-kidney, one clip renal artery stenosis of 2 days' duration (2-day clipped rat) and in rabbits with renal artery stenosis of 3 days' duration (3-day clipped rabbits). The 2-day clipped rats showed hyperresponsiveness to norepinephrine (NE), arginine vasopressin (AVP) and 5-HT. All hyperresponsiveness were attenuated by a subdepressor dose of KET. The infusion of KET, 10 micrograms/kg/min for 30 minutes, decreased mean arterial pressure of the 3-day clipped rabbits; the dose did not alter blood pressure of the normal controls. Exaggerated pressor response to NE was observed in the 3-day clipped rabbits and was abolished by a subdepressor dose of KET, 2.5 micrograms/kg/min. These results suggest that 5-HT may be involved in the enhanced pressor response to vasoconstrictor substances in the 2-day clipped rats and 3-day clipped rabbits, and that it may also play an important role in maintaining blood pressure in the 3-day clipped rabbits.
在病程为2天的单肾单夹肾动脉狭窄大鼠（2天夹闭大鼠）和病程为3天的肾动脉狭窄家兔（3天夹闭家兔）中，研究了特异性5-羟色胺2（5-HT2）受体阻滞剂酮色林（KET）对血管活性物质升压反应的影响。2天夹闭大鼠对去甲肾上腺素（NE）、精氨酸加压素（AVP）和5-羟色胺表现出反应过度。所有过度反应均被亚降压剂量的KET减弱。以10微克/千克/分钟的剂量输注KET 30分钟，可降低3天夹闭家兔的平均动脉压；该剂量对正常对照的血压无影响。在3天夹闭家兔中观察到对NE的升压反应增强，而2.5微克/千克/分钟的亚降压剂量KET可消除这种反应。这些结果表明，5-羟色胺可能参与了2天夹闭大鼠和3天夹闭家兔对血管收缩物质增强的升压反应，并且它可能在维持3天夹闭家兔的血压中也起重要作用。
