Kogure M, Ichikawa S, Yagi S, Sato K, Fujita H, Fujie M, Kumakura H, Yagi A, Nakamura T, Murata K
Life Sci. 1987 Mar 30;40(13):1277-86. doi: 10.1016/0024-3205(87)90584-4.
The role of prostaglandins (PGs) in the pressor response to norepinephrine (NE) was examined in one-kidney, one clip rabbits with renal artery stenosis for 3-day's duration (3-day clipped rabbits) and in sham operated rabbits with one-kidney without renal artery stenosis. An exaggerated pressor response to NE, 800 ng/kg/min, was observed in the 3-day clipped rabbits, and it was abolished by angiotensin II antagonist, [Sar1, Ile8] angiotensin II (AIIA). Treatment with indomethacin, 10 mg/kg, induced hyperresponsiveness to NE in the sham operated rabbits and also produced a further increase in the response in the 3-day clipped rabbits: the enhanced responses with similar levels were not attenuated by AIIA in both groups. A subdepressor dose of PGE2, 800 ng/kg/min, abolished the hyperresponsiveness in the 3-day clipped rabbits, while subdepressor or depressor dose of PGI2, 10 or 20 ng/kg/min did not, but the concurrent infusion of AIIA with PGI2 attenuated it. These results indicate that PGs, in particular PGE2 might be involved in the enhanced pressor response to NE in the 3-day clipped rabbits in addition to the altered renin-angiotensin system.
在肾动脉狭窄3天的单肾单夹兔（3天夹闭兔）和假手术的无肾动脉狭窄单肾兔中，研究了前列腺素（PGs）在去甲肾上腺素（NE）升压反应中的作用。在3天夹闭兔中观察到对800 ng/kg/min NE的升压反应增强，并且该反应被血管紧张素II拮抗剂[Sar1，Ile8]血管紧张素II（AIIA）消除。用10 mg/kg吲哚美辛处理，在假手术兔中诱导了对NE的高反应性，并且在3天夹闭兔中也使反应进一步增加：两组中类似水平的增强反应均未被AIIA减弱。亚降压剂量的PGE2（800 ng/kg/min）消除了3天夹闭兔中的高反应性，而亚降压或降压剂量的PGI2（10或20 ng/kg/min）则没有，但AIIA与PGI2同时输注可使其减弱。这些结果表明，除了肾素-血管紧张素系统改变外，PGs，特别是PGE2可能参与了3天夹闭兔中对NE增强的升压反应。
