Sakai K, Fujimoto M, Nakamura T, Hashimoto I, Sawada Y, Suzuki T, Yura J, Ishikawa S, Taguchi T, Ota J
Jpn J Antibiot. 1986 Nov;39(11):2938-44.
A clinical evaluation of astromicin (ASTM) administered by intravenous drip infusion against infections in the surgical field was made, and the results were summarized as follows. Excellent effect was observed in 19 out of a total of 44 cases, good effect in 19, fair in 1 and poor in 5. The efficacy rate calculated from the 38 cases of "excellent" and "good" was 86%. In stratification by disease, the efficacy rate was 91% in localized peritonitis (31/34 cases) and 63% in diffuse peritonitis (5/8 cases); the overall efficacy rate in peritonitis was 86%. The efficacy rate in 2 cases infected by Gram-positive bacteria was 50%, and that in 16 cases by Gram-negative bacteria was 94%. The disappearance rate of Gram-negative bacteria was 93%, and this drug was especially effective against E. coli. There were no subjective or objective side effects and no abnormal laboratory test values that were related to the administration of ASTM.
对静脉滴注阿贝卡星（ASTM）治疗手术部位感染进行了临床评估，结果总结如下。44例患者中，19例疗效极佳，19例疗效良好，1例疗效一般，5例疗效较差。根据38例“极佳”和“良好”病例计算的有效率为86%。按疾病分层，局限性腹膜炎的有效率为91%（31/34例），弥漫性腹膜炎的有效率为63%（5/8例）；腹膜炎的总体有效率为86%。2例革兰氏阳性菌感染患者的有效率为50%，16例革兰氏阴性菌感染患者的有效率为94%。革兰氏阴性菌的清除率为93%，该药物对大肠杆菌特别有效。未观察到与阿贝卡星给药相关的主观或客观副作用，实验室检查值也无异常。
