Lin Yi, Liang Xiao, Zhang Xijie, Ni Yanghong, Zhou Xiaoting, Zhao Xia
Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, West China Second Hospital, Sichuan University, 610041 Chengdu, Sichuan, China.
Front Biosci (Landmark Ed). 2022 Apr 20;27(4):139. doi: 10.31083/j.fbl2704139.
Conventional treatments for ovarian cancer, including debulking cytoreductive surgery combined with carboplatin/paclitaxel-based chemotherapy, are insufficient, as evidenced by the high mortality rate, which ranks first among gynecological tumors. Therefore, there is an urgent need to develop new and effective treatment strategies. Recent evidence has shown that metabolic processes and cell behaviors in ovarian cancer are regulated by intracellular factors as well as metabolites in the tumor microenvironment (TME), which determine occurrence, proliferation, and metastasis. In this review, we describe the comprehensive landscape of metabolic cross-talk between ovarian cancer and its TME with a focus on the following four aspects: (1) intracellular metabolism based on the Warburg effect, (2) metabolism in non-tumor cells in the ovarian TME, (3) metabolic communication between tumor cells and non-tumor cells in the TME, and (4) metabolism-related therapeutic targets and agents for ovarian cancer. The metabolic cross-talk between ovarian cancer and its microenvironment involves a complex network of interactions, and interrupting these interactions by metabolic interventions is a promising therapeutic strategy.
卵巢癌的传统治疗方法，包括减瘤细胞减灭术联合以卡铂/紫杉醇为基础的化疗，并不充分，这一点从其高死亡率可见一斑，卵巢癌死亡率在妇科肿瘤中位居首位。因此，迫切需要开发新的有效治疗策略。最近的证据表明，卵巢癌中的代谢过程和细胞行为受细胞内因子以及肿瘤微环境（TME）中的代谢物调控，这些因素决定了肿瘤的发生、增殖和转移。在本综述中，我们描述了卵巢癌与其TME之间代谢相互作用的全貌，重点关注以下四个方面：（１）基于瓦伯格效应的细胞内代谢；（２）卵巢TME中非肿瘤细胞的代谢；（３）TME中肿瘤细胞与非肿瘤细胞之间的代谢通讯；（４）卵巢癌的代谢相关治疗靶点和药物。卵巢癌与其微环境之间的代谢相互作用涉及一个复杂的相互作用网络，通过代谢干预中断这些相互作用是一种很有前景的治疗策略。
