Zhang Qian, Tong Lihong, Wang Bing, Wang Ting, Ma Hongxia
Pneumology Department, The Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi City, People's Republic of China.
Ther Clin Risk Manag. 2022 Apr 19;18:429-437. doi: 10.2147/TCRM.S349185. eCollection 2022.
Correlations between idiopathic pulmonary fibrosis (IPF) and lung cancer have been discussed in many previous studies. In the present work, we evaluated the potential diagnostic value of serum levels of Th17 cell-related cytokines for the detection of lung cancer-associated IPF.
Fifty-six patients who had been diagnosed with lung cancer-associated IPF were enrolled, and 59 patients with lung cancer but without IPF were also enrolled, and 60 healthy volunteers were served as the control group. The expression of IL-22, IL-23, and IL-17 was evaluated by enzyme-linked immunosorbent assay (ELISA) kits.
We observed that IL-22, IL-23 as well as IL-17 were significantly increased in the serum of lung cancer patients associated IPF; moreover, the results of ROC curve showed that the expression of IL-22, IL-23 and IL-17 can distinguish the lung cancer patients with lung cancer-associated IPF group; finally, the expression of IL-22, IL-23 and IL-17 was positively correlated with the degree of differentiation and metathesis of the tumor.
In conclusion, we first reported that IL-22, IL-23 and IL-17 were elevated in the serum of patients with lung cancer-associated IPF, and our data may provide novel evidence for the prevention and treatment of lung cancer-associated IPF.
既往许多研究都探讨了特发性肺纤维化（IPF）与肺癌之间的相关性。在本研究中，我们评估了血清中Th17细胞相关细胞因子水平对肺癌相关IPF检测的潜在诊断价值。
纳入56例已确诊为肺癌相关IPF的患者，59例患有肺癌但无IPF的患者，60名健康志愿者作为对照组。采用酶联免疫吸附测定（ELISA）试剂盒评估白细胞介素-22（IL-22）、白细胞介素-23（IL-23）和白细胞介素-17（IL-17）的表达。
我们观察到，IL-22、IL-23以及IL-17在肺癌相关IPF患者血清中显著升高；此外，ROC曲线结果显示，IL-22、IL-23和IL-17的表达可区分肺癌相关IPF组的肺癌患者；最后，IL-22、IL-23和IL-17的表达与肿瘤的分化程度和转移呈正相关。
总之，我们首次报道IL-22、IL-23和IL-17在肺癌相关IPF患者血清中升高，我们的数据可能为肺癌相关IPF的防治提供新的证据。
