添加黑色素的负载别嘌醇的淀粉基生物材料的合成及其药物释放性能
Synthesis and drug release properties of melanin added functional allopurinol incorporated starch-based biomaterials.
作者信息
Kim Han-Seong, Lee Chang-Moon, Yun Yeon-Hum, Kim Youn-Sop, Yoon Soon-Do
机构信息
Department of Biomolecular and Chemical Engineering, Chonnam National University, Jeonnam 59626, South Korea.
Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeonnam 59626, Republic of Korea.
出版信息
Int J Biol Macromol. 2022 Jun 1;209(Pt A):1477-1485. doi: 10.1016/j.ijbiomac.2022.04.116. Epub 2022 Apr 22.
The main objective of this study was to prepare functional allopurinol (ALP) incorporated biomaterials using mungbean starch, polyvinyl alcohol, melanin (MEL), and plasticizers. Prepared biomaterials were characterized by FE-SEM and FT-IR analysis. Photothermal conversion efficiencies and ALP release properties of biomaterials were evaluated with NIR laser irradiation. When biomaterials were irradiated with the NIR laser, temperatures increase of MEL-added biomaterials were higher than those of MEL-non-added biomaterials. After NIR laser irradiation, ALP release rates of MEL-added biomaterials were 1.62 times faster than those of MEL-non-added biomaterials. In addition, ALP release using an artificial skin was increased by NIR laser irradiation. ALP release from biomaterials followed Fickian diffusion mechanism, while ALP release using an artificial skin followed a non-Fickian diffusion mechanism. Xanthine oxidase inhibitory (%) for MEL-added biomaterials with/without the addition of GL and XL were 47.5%, 61.7%, and 65.1%, respectively.
本研究的主要目的是使用绿豆淀粉、聚乙烯醇、黑色素（MEL）和增塑剂制备负载功能化别嘌醇（ALP）的生物材料。通过场发射扫描电子显微镜（FE-SEM）和傅里叶变换红外光谱（FT-IR）分析对制备的生物材料进行表征。利用近红外（NIR）激光照射评估生物材料的光热转换效率和ALP释放特性。当用NIR激光照射生物材料时，添加MEL的生物材料的温度升高高于未添加MEL的生物材料。在NIR激光照射后，添加MEL的生物材料的ALP释放速率比未添加MEL的生物材料快1.62倍。此外，使用人工皮肤时，NIR激光照射会增加ALP的释放。生物材料中ALP的释放遵循菲克扩散机制，而使用人工皮肤时ALP的释放遵循非菲克扩散机制。添加/未添加GL和XL的添加MEL的生物材料的黄嘌呤氧化酶抑制率（%）分别为47.5%、61.7%和65.1%。
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