Gallacher John, Pickering Janet, Bayer Anthony, Heslop Luke, Morgan Gareth, Watkins Angela, Martin Rhodri, Elwood Peter
Department of Psychiatry, University of Oxford, England, United Kingdom.
Division of Population Medicine, PRIME Centre Wales, Cardiff University, Cardiff, Wales, United Kingdom.
Clin J Sport Med. 2022 May 1;32(3):329-333. doi: 10.1097/JSM.0000000000000976. Epub 2021 Sep 15.
To examine the long-term effects of amateur boxing in a representative population sample of men.
The sample was examined every 5 years for 35 years. Cognition was assessed repeatedly from the third examination. Previous boxing experience and dementia were assessed at the fifth examination, and dementia assessed subsequently through medical records.
The Caerphilly Prospective Study investigates risk factors for a range of chronic diseases of diseases. These include life style and behavior, together with biological factors relevant to vascular disease.
1123 adult men aged 45 to 59 years at baseline, followed for 35 years.
Cognitive impairment.
A report by a subject of having boxed "seriously" when younger was associated with a 2-fold increase in cognitive impairment [odds ratio (OR) = 2.27; 95% confidence intervals = 1.18-4.38]. For amnestic (Alzheimer-like) impairment, this rises to OR = 2.78 (95% confidence limits 1.37-5.65). Having boxed is associated with an "advancement" in the onset of the dementia (4.8 years; 95% confidence limits 0.9-8.8 years).
Amateur boxing is associated with an increased risk and an earlier onset of cognitive impairment and dementia.
在具有代表性的男性人群样本中研究业余拳击的长期影响。
对样本进行为期35年的每5年一次的检查。从第三次检查开始反复评估认知情况。在第五次检查时评估既往拳击经历和痴呆情况，随后通过病历评估痴呆情况。
卡菲利前瞻性研究调查一系列慢性疾病的危险因素。这些因素包括生活方式和行为，以及与血管疾病相关的生物学因素。
1123名年龄在45至59岁之间的成年男性作为基线样本，随访35年。
认知障碍。
一名受试者报告年轻时“认真”拳击与认知障碍增加2倍相关[比值比（OR）=2.27；95%置信区间=1.18 - 4.38]。对于遗忘型（阿尔茨海默样）障碍，该比值比升至OR = 2.78（95%置信区间1.37 - 5.65）。拳击与痴呆发病“提前”相关（4.8年；95%置信区间0.9 - 8.8年）。
业余拳击与认知障碍和痴呆风险增加及发病提前有关。
