The Effect of Age and Sex on Ischemıc Stroke: A Sıngle-Centred Neuro-Intensıve Care Unıt Experıence.

BACKGROUND

Age and sex are important determinants in the acute ischemic stroke (AIS). In this study, we examine the effects of age and sex on stroke survival and treatment in our clinic.

METHODS

We reviewed 368 AIS patients' records between January 1, 2019, and January 1, 2020, and formed three groups of age; Group 1:18-64 years, Group 2:65-79 years, and Group 3:more than 80 years. Then, we analyzed patients' data (sex, risk factors, hospital outcome, etc.), reperfusion therapy (RT) types (tissue plasminogen activator(tPA), endovascular therapy(EVT) and tPA+EVT), and reasons for none- RT (time mismatch, absolute and relative contraindications).

RESULTS

The majority of patients were age less than 65 years (48.6%), and the proportion of women increased in the older (56.1%). The most common stroke risk factor was hypertension (44.7%), but for those less than 65 years, it was obesity (46.6%). The most common RT type was tPA (56.7%), and no patients more than 80 years received tPA+EVT. The most common none-RT reason was time mismatch (65%). Being more than 80 years and female over 80 years (p=0.001, and p=0.005) were associated with increased mortality risk. While the frequency of none-RT patients was 28.8% in general, it increased up to 62.8% for the ones age more than 80 years. Also, the mortality rate was the highest in the none-RT(p less than 0.01).

CONCLUSIONS

RT practices differed according to patients' age and sex. The main determinant of the mortality rate was the lack of RT. However, the older patients and older women had less opportunity for RT.