Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou, China.
Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, China.
Basic Clin Pharmacol Toxicol. 2022 Jul;131(1):74-82. doi: 10.1111/bcpt.13734. Epub 2022 May 4.
Long-acting anticoagulant rodenticide (LAAR) poisoning remains a serious public health problem. The aim of this study was to explore the clinical characteristics of different LAARs and a method of making a decision on the VK1 treatment course and the time to stop VK1 treatment safely.
This retrospective study compared the clinical characteristics of two LAARs poisoning patients and used multivariate regression method to explore the relationship between blood LAAR concentration and vitamin K1 dose/treatment time.
A total of 115 patients with LAAR poisoning were included in this study after screening. Of these, 50 patients attempted to commit suicide. The median LAAR concentration of the patients at admission was 409 (157-1174) ng/mL, and the VK1 treatment duration was 14 (8-34) days. The total VK1 treatment time in patients with LAAR poisoning was positively correlated with admission LAAR concentration. During the maintenance treatment period, the VK1 dosage was positively correlated with blood LAAR concentration.
Low dose of VK1 during the maintenance period is indicative of the blood LAAR concentration being relatively low. This provides a basis for judging the LAAR content in the body during the maintenance treatment period.
长效抗凝血灭鼠剂（LAAR）中毒仍然是一个严重的公共卫生问题。本研究旨在探讨不同 LAAR 中毒的临床特征，以及一种决定 VK1 治疗疗程和安全停止 VK1 治疗时间的方法。
本回顾性研究比较了两名 LAAR 中毒患者的临床特征，并采用多元回归方法探讨了血 LAAR 浓度与维生素 K1 剂量/治疗时间之间的关系。
筛选后共纳入 115 名 LAAR 中毒患者，其中 50 名患者企图自杀。入院时患者的 LAAR 浓度中位数为 409（157-1174）ng/mL，VK1 治疗时间为 14（8-34）天。LAAR 中毒患者的总 VK1 治疗时间与入院时 LAAR 浓度呈正相关。在维持治疗期间，VK1 剂量与血 LAAR 浓度呈正相关。
维持治疗期间低剂量的 VK1 表明血 LAAR 浓度相对较低。这为判断维持治疗期间体内 LAAR 含量提供了依据。
