α-二羰基和α-羟基羰基化合物对诱变杂环胺的抗诱变作用。

Desmutagenic effect of alpha-dicarbonyl and alpha-hydroxycarbonyl compounds against mutagenic heterocyclic amines.

作者信息

Kim S B, Hayase F, Kato H

出版信息

Mutat Res. 1987 Mar;177(1):9-15. doi: 10.1016/0027-5107(87)90016-9.

Abstract

The desmutagenic effects of alpha-hydroxycarbonyl compounds, such as glyceraldehyde, glycolaldehyde, dihydroxyacetone, furfural, 5-hydroxymethylfurfural, maltol, acetol and acetoin and alpha-dicarbonyl compounds, such as diacetyl, glyoxal, methyl glyoxal and 2,3-pentanedione were investigated against the mutagenic heterocyclic amines, such as Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2 and IQ. Most of the carbonyl compounds suppressed the mutagenicity of heterocyclic amines for S. typhimurium TA98, alpha-dicarbonyl compounds showing a higher desmutagenic effect than alpha-hydroxycarbonyl compounds. Among the alpha-hydroxycarbonyl compounds, glyceraldehyde, glycolaldehyde and dihydroxyacetone showed more effective desmutagenicity, and diacetyl among the alpha-dicarbonyl compounds had the highest desmutagenic effect. These carbonyl compounds alone also showed mutagenicity to S. typhimurium TA100 without S9 mix. The reaction of carbonyl compounds with mutagenic heterocyclic amines also eliminated the mutagenicity of the former for S. typhimurium TA100.

摘要

研究了α-羟基羰基化合物（如甘油醛、乙醇醛、二羟基丙酮、糠醛、5-羟甲基糠醛、麦芽酚、丙酮醇和乙偶姻）以及α-二羰基化合物（如双乙酰、乙二醛、甲基乙二醛和2,3-戊二酮）对诱变杂环胺（如Trp-P-1、Trp-P-2、Glu-P-1、Glu-P-2和IQ）的抗诱变作用。大多数羰基化合物抑制了杂环胺对鼠伤寒沙门氏菌TA98的诱变性，α-二羰基化合物的抗诱变作用高于α-羟基羰基化合物。在α-羟基羰基化合物中，甘油醛、乙醇醛和二羟基丙酮表现出更有效的抗诱变作用，而在α-二羰基化合物中，双乙酰的抗诱变作用最高。这些羰基化合物单独使用时，在无S9混合液的情况下对鼠伤寒沙门氏菌TA100也表现出诱变性。羰基化合物与诱变杂环胺的反应也消除了前者对鼠伤寒沙门氏菌TA100的诱变性。