咖啡中甲基乙二醛的致突变性。

Mutagenicity of methylglyoxal in coffee.

作者信息

Kasai H, Kumeno K, Yamaizumi Z, Nishimura S, Nagao M, Fujita Y, Sugimura T, Nukaya H, Kosuge T

出版信息

Gan. 1982 Oct;73(5):681-3.

Abstract

Major carbonyl compounds from a extract of ground roasted coffee beans were identified as 5-hydroxymethylfurfural, acetol, glyoxal, methylglyoxal and diacetyl. Among these carbonyl compounds, methylglyoxal showed considerable mutagenic activity toward Salmonella typhimurium TA100 without S9 mix (around 100,000 revertants/mg). More than 50% of the total mutagenic activity of coffee can be accounted for by the activity of methylglyoxal.

摘要

研磨烘焙咖啡豆提取物中的主要羰基化合物被鉴定为5-羟甲基糠醛、丙酮醇、乙二醛、甲基乙二醛和双乙酰。在这些羰基化合物中，甲基乙二醛对鼠伤寒沙门氏菌TA100在无S9混合液的情况下表现出相当大的诱变活性（约100,000回复突变体/毫克）。咖啡总诱变活性的50%以上可由甲基乙二醛的活性来解释。