Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India.
Department of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj, 11942, Saudi Arabia.
Phytochemistry. 2022 Aug;200:113213. doi: 10.1016/j.phytochem.2022.113213. Epub 2022 Apr 25.
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and anti-inflammatory properties, validated in various disease models. The anti-cancer potential of TQ is goverened by anti-proliferation, cell cycle arrest, apoptosis induction, ROS production, anti-metastasis and anti-angiogenesis, inhibition of cell migration and invasion action. Additionally, TQ exhibited antitumor activity via the modulation of multiple pathways and molecular targets, including Akt, ERK1/2, STAT3, and NF-κB. The present review highlighted the anticancer potential of TQ . We summarize the anti-cancer, anti-oxidant, and anti-inflammatory properties of TQ, focusing on its molecular targets and its promising action in cancer therapy. We further described the molecular mechanisms by which TQ prevents signaling pathways that mediate cancer progression, invasion, and metastasis.
姜黄色素（TQ）是一种主要存在于黑种草中的天然植物化学物质，因其多种健康益处而受到研究。TQ 具有抗癌、抗氧化和抗炎特性，已在各种疾病模型中得到验证。TQ 的抗癌潜力受抗增殖、细胞周期阻滞、凋亡诱导、ROS 产生、抗转移和抗血管生成、抑制细胞迁移和侵袭作用的控制。此外，TQ 通过调节多种途径和分子靶点，包括 Akt、ERK1/2、STAT3 和 NF-κB，表现出抗肿瘤活性。本综述强调了 TQ 的抗癌潜力。我们总结了 TQ 的抗癌、抗氧化和抗炎特性，重点介绍了其分子靶点及其在癌症治疗中的有前途的作用。我们进一步描述了 TQ 防止介导癌症进展、侵袭和转移的信号通路的分子机制。
