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神经科学与动作计量学:精确测量行为带来益处的范例

Neuroscience and actometry: An example of the benefits of the precise measurement of behavior.

机构信息

National Institute on Drug Abuse, 301 North Stonestreet Ave, Bethesda, MD 20892, USA.

出版信息

Brain Res Bull. 2022 Jul;185:86-90. doi: 10.1016/j.brainresbull.2022.04.009. Epub 2022 Apr 25.

DOI:10.1016/j.brainresbull.2022.04.009
PMID:35472566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9167777/
Abstract

PURPOSE

Assess the impact the force-plate actometer, invented by Stephen C. Fowler, has had on behavioral neuroscience so far and what may be possible for future progress.

METHODS

The web service Scopus was queried on April 28, 2021 for articles that cited the Journal of Neuroscience Methods paper titled "A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor" resulting in 134 articles. Articles were coded by the author for type (e.g., research, review, book chapter), phenomenon (e.g., stress, addiction), intervention (e.g., pharmacological), and measure (e.g., distance traveled, tremor).

CONCLUSIONS

Of the 134 citations, 116 were research articles, 10 were review articles, 7 were book chapters and one was an advertisement. The force-plate actometer has been used to study a variety of phenomena and its measurement capabilities were expanded. While primarily used for rats and mice, other species have been used.

摘要

目的

评估 Stephen C. Fowler 发明的测力板活动计对行为神经科学的影响,以及未来可能取得的进展。

方法

作者于 2021 年 4 月 28 日通过网络服务 Scopus 对引用了题为“用于量化啮齿动物行为的测力板活动计:关于运动、旋转、空间模式、刻板行为和震颤的说明性数据”的《神经科学方法杂志》论文的文章进行了查询,共得到 134 篇文章。作者对文章进行了编码,分类依据为类型(如研究、综述、书籍章节)、现象(如应激、成瘾)、干预措施(如药理学)和测量(如行进距离、震颤)。

结论

在这 134 篇引用文献中,116 篇为研究文章,10 篇为综述文章,7 篇为书籍章节,1 篇为广告。测力板活动计已被用于研究各种现象,并扩展了其测量能力。虽然主要用于大鼠和小鼠,但也有其他物种被使用。

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Objective detection of microtremors in netrin-G2 knockout mice.检测 netrin-G2 敲除小鼠中的微震颤。
J Neurosci Methods. 2021 Mar 1;351:109074. doi: 10.1016/j.jneumeth.2021.109074. Epub 2021 Jan 13.
2
Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor.小脑核内帕伐洛宾神经元功能障碍可引起动作性震颤。
J Clin Invest. 2020 Oct 1;130(10):5142-5156. doi: 10.1172/JCI135802.
3
Cell-autonomous expression of the acid hydrolase galactocerebrosidase.细胞自主表达酸性水解酶半乳糖脑苷脂酶。
Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):9032-9041. doi: 10.1073/pnas.1917675117. Epub 2020 Apr 6.
4
Regulation of defeat-induced social avoidance by medial amygdala DRD1 in male and female prairie voles.内侧杏仁核 DRD1 调节雄性和雌性草原田鼠的挫败诱导性社交回避
Psychoneuroendocrinology. 2020 Mar;113:104542. doi: 10.1016/j.psyneuen.2019.104542. Epub 2019 Dec 16.
5
Altered Primary Motor Cortex Neuronal Activity in a Rat Model of Harmaline-Induced Tremor During Thalamic Deep Brain Stimulation.在丘脑深部脑刺激期间,harmaline诱导的震颤大鼠模型中初级运动皮层神经元活动的改变
Front Cell Neurosci. 2019 Oct 15;13:448. doi: 10.3389/fncel.2019.00448. eCollection 2019.
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Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target.酸性鞘磷脂酶基因敲除确认脑苷脂病的神经涎酸假说,并鉴定新的治疗靶点。
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