衰老小鼠模型中的焦虑和任务表现变化。
Anxiety and task performance changes in an aging mouse model.
机构信息
Department of Pharmacology and Toxicology, Higuchi Bioscience Center, University of Kansas, Lawrence, KS 66047, USA.
Department of Pharmacology and Toxicology, Higuchi Bioscience Center, University of Kansas, Lawrence, KS 66047, USA.
出版信息
Biochem Biophys Res Commun. 2019 Jun 18;514(1):246-251. doi: 10.1016/j.bbrc.2019.04.049. Epub 2019 Apr 24.
Abstract
Due to the increasing focus on aging as an important risk factor for many serious diseases and an emphasis on animal models that have translational value, an increasing number of animal models are being aged. Animal behavior tests can be used to assess effects of aging in mouse models. Female mice begin exhibiting anxiety-like behaviors at 12 months of age which become more serious at 24 months, while males exhibit no age-induced anxiety-like behaviors. Males and females equally demonstrate a failure of daily task performance at 24 months. Despite these cognitive changes, the mice do not show changes in gross motor function. These results suggest cognitive impairment in non-genetically modified aging mice.
摘要
由于人们越来越关注衰老作为许多严重疾病的重要风险因素，并强调具有转化价值的动物模型，因此越来越多的动物模型正在衰老。动物行为测试可用于评估小鼠模型衰老的影响。雌性小鼠在 12 个月大时开始表现出类似焦虑的行为，而在 24 个月大时变得更加严重，而雄性小鼠则没有表现出与年龄相关的焦虑行为。雄性和雌性小鼠在 24 个月时同样表现出日常任务执行能力的下降。尽管存在这些认知变化，但这些小鼠并没有出现运动功能障碍。这些结果表明，非基因修饰的衰老小鼠存在认知障碍。
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