Pacheco Y, Fonlupt P, Dubois M, Biot N, Perrin-Fayolle M, Pacheco H
Pathol Biol (Paris). 1986 Dec;34(10):1067-73.
Alveolar macrophage plays an important role in alveolitis pathogenesis and lung fibrosis process. Macrophages exhibit plasmic membrane biochemical modifications during cell activation. Phospholipid methylation is involved during plasmic membrane stimulation. Phosphatidylethanolamine methyltransferase I was measured in alveolar macrophage membrane from normal subjects and patients presenting with pulmonary sarcoidosis or interstitial lung fibrosis. We observed increased enzyme activity among sarcoidosis subjects with high intensity lung alveolitis and normal subjects receiving immunostimulating treatment (RU 41740). The role of membrane phospholipidic modifications in granulomatous process is discussed.
肺泡巨噬细胞在肺泡炎发病机制和肺纤维化过程中起重要作用。巨噬细胞在细胞激活过程中表现出质膜生化修饰。磷脂甲基化参与质膜刺激过程。在正常受试者以及患有结节病或间质性肺纤维化的患者的肺泡巨噬细胞膜中检测了磷脂酰乙醇胺甲基转移酶I。我们观察到，在患有高强度肺泡炎的结节病患者以及接受免疫刺激治疗（RU 41740）的正常受试者中，酶活性增加。本文讨论了膜磷脂修饰在肉芽肿形成过程中的作用。
