Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Alzheimers Dement. 2023 Feb;19(2):498-506. doi: 10.1002/alz.12681. Epub 2022 Apr 26.
The nature and course of limitations in everyday function in the early clinical stages of cognitive decline is not well known.
We compared complex everyday functional profiles at baseline in 59 community-dwelling older individuals with normal cognitive performance who went on to develop incident mild cognitive impairment (MCI) ("pre-MCI") with 284 older individuals who remained cognitively normal over follow-up.
The mean number of limitations on complex everyday function at baseline was 3.1 ± 3.0 in the 59 pre-MCI cases and 2.0 ± 2.4 in the 284 normal controls (P = .003). Pre-MCI cases had limitations in traveling, entertaining, remembering appointments, and hobbies compared to normal controls. A progressive increase in mild limitations on complex everyday function preceded the incidence of MCI (mean change: pre-MCI 1.9 ± 3.6 vs normal controls 0.5 ± 2.7, P < .001).
Prodromal stages of MCI are associated with progressive mild limitations in complex activities of daily living.
认知能力下降早期阶段日常功能受限的性质和过程尚不清楚。
我们比较了基线时 59 名认知功能正常的社区居住的老年人中存在的复杂日常功能障碍的情况，这些人后来发展为轻度认知障碍（MCI）（“预 MCI”），并与 284 名在随访期间认知功能正常的老年人进行了比较。
59 例预 MCI 病例的基线时复杂日常功能受限的平均数量为 3.1 ± 3.0，284 例正常对照组为 2.0 ± 2.4（P =.003）。与正常对照组相比，预 MCI 病例在旅行、娱乐、约会和爱好方面存在障碍。在 MCI 发生之前，复杂日常功能的轻度限制逐渐增加（平均变化：预 MCI 1.9 ± 3.6 与正常对照组 0.5 ± 2.7，P <.001）。
MCI 的前驱阶段与日常生活中复杂活动的逐渐轻度受限有关。
