具有抗乳腺癌潜力的 1,2,3-三唑衍生物。
1,2,3-Triazole Derivatives with Anti-breast Cancer Potential.
作者信息
Wu Xinyi, Wang Jun, Xia Shiqi, Cheng Shishuo, Shi Yumin
机构信息
School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.
出版信息
Curr Top Med Chem. 2022;22(17):1406-1425. doi: 10.2174/1568026622666220415225334.
Breast cancer is one of the most prevalent malignant diseases, and one of the main causes of mortality among women across the world. Despite advances in chemotherapy, drug resistance remains a major clinical concern, creating an urgent need to explore novel anti-breast cancer drugs. 1,2,3-triazole is a privileged moiety, and its derivatives could inhibit cancer cell proliferation and induce cell cycle arrest and apoptosis. Accordingly, 1,2,3-triazole derivatives possess profound activity against various cancers, including breast cancer. This review summarizes the latest progress related to the anti-breast cancer potential of 1,2,3-triazole derivatives, covering articles published from January 2017 to December 2021. The mechanisms of action and structure-activity relationships (SARs) are also discussed for the further rational design of more effective candidates.
乳腺癌是最常见的恶性疾病之一，也是全球女性死亡的主要原因之一。尽管化疗取得了进展，但耐药性仍然是一个主要的临床关注点，因此迫切需要探索新型的抗乳腺癌药物。1,2,3-三唑是一种优势基团，其衍生物可以抑制癌细胞增殖，并诱导细胞周期停滞和细胞凋亡。因此，1,2,3-三唑衍生物对包括乳腺癌在内的各种癌症具有深远的活性。本综述总结了 2017 年 1 月至 2021 年 12 月期间发表的与 1,2,3-三唑衍生物抗乳腺癌潜力相关的最新进展。还讨论了作用机制和构效关系（SAR），以进一步合理设计更有效的候选药物。
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