Department of Pharmacology, Faculty of Pharmacy, Near East University, 99138, Lefkosa, TRNC, Turkey.
Department of Pharmacology, Faculty of Dentistry, Near East University, Lefkosa, TRNC, Turkey.
Mol Biol Rep. 2022 May;49(5):4055-4059. doi: 10.1007/s11033-022-07384-3. Epub 2022 Apr 26.
Gastrointestinal mucositis is a common and dose-limiting side effect characterized by ulcerative lesions in the mucosa of the digestive tract in patients receiving anticancer drugs such as 5-fluorouracil (5-FU), a potent antineoplastic drug. Several protocols have reported the efficacy of therapeutic interventions to prevent this side effect, although complete success has not yet been achieved and mucositis remains one of the most serious complications associated with 5-FU therapy. Oxytocin, a well-known antistress agent, has been reported to have comparable effects to ranitidine. Previous studies have shown that oxytocin inhibits gastric acid secretion and the expression of proinflammatory cytokines in rats. If oxytocin can reduce stress-induced ulcers via antioxidant, antiapoptotic, and anti-inflammatory pathways, then it may have a dose-dependent effect on gastrointestinal mucositis caused by 5-FU.
胃肠道黏膜炎是一种常见的剂量限制副作用，其特征是接受抗癌药物（如 5-氟尿嘧啶（5-FU））治疗的患者的消化道黏膜出现溃疡性损伤。有几个方案报告了治疗干预措施预防这种副作用的疗效，尽管尚未取得完全成功，并且黏膜炎仍然是与 5-FU 治疗相关的最严重的并发症之一。催产素是一种众所周知的抗应激剂，其效果可与雷尼替丁相媲美。先前的研究表明，催产素可抑制大鼠胃酸分泌和促炎细胞因子的表达。如果催产素可以通过抗氧化、抗凋亡和抗炎途径减少应激性溃疡，那么它可能对 5-FU 引起的胃肠道黏膜炎具有剂量依赖性作用。
