Hoffmann P, Taube C, Förster W, Weinert D, Grosse W R, Balschun D, Schuh J
Prostaglandins Leukot Med. 1986 Dec;25(2-3):91-103. doi: 10.1016/0262-1746(86)90057-0.
Circadian rhythms of eicosanoid formation were investigated in linoleic acid (LA) rich (sunflower seed oil, 13.3 cal% LA) and LA deficient (hydrogenated palm kernel fat, 0.5 cal% LA) diet fed male Wistar rats adapted to an artificial lighting regimen of 12 hours light and 12 hours darkness. Over a period of 24 hours we examined at 4 hour intervals eicosanoid formation in the aorta (PGI2, PGE, PGF2 alpha), in the heart (6-keto-PGF1 alpha, PGE, PGF2 alpha, TXB2), in the kidney (PGE, PGF2 alpha) and in the brain (PGE, PGF2 alpha). Two types of circadian variation curves were observed: Low eicosanoid formation in the light period and increase in the dark cycle (PGE in aorta and heart, TXB2 in heart). The increase in eicosanoid formation in the dark cycle was diminished after an LA deficient diet. Continuous decrease (PGI2 in aorta) and increase (PGE in the brain), respectively, in the course of the day, without differences between the two dietary groups. We assume that the circadian oscillations of eicosanoid formation might be of importance for the development of the circadian time structure of the organism.
在适应12小时光照和12小时黑暗人工光照方案的雄性Wistar大鼠中，研究了富含亚油酸（LA）（向日葵籽油，13.3千卡%LA）和LA缺乏（氢化棕榈仁油，0.5千卡%LA）饮食情况下类花生酸形成的昼夜节律。在24小时内，我们每隔4小时检查主动脉（前列环素I2、前列腺素E、前列腺素F2α）、心脏（6-酮-前列腺素F1α、前列腺素E、前列腺素F2α、血栓素B2）、肾脏（前列腺素E、前列腺素F2α）和大脑（前列腺素E、前列腺素F2α）中类花生酸的形成。观察到两种类型的昼夜变化曲线：光照期类花生酸形成量低，黑暗周期增加（主动脉和心脏中的前列腺素E，心脏中的血栓素B2）。缺乏LA饮食后，黑暗周期中类花生酸形成的增加减少。在一天中分别持续下降（主动脉中的前列环素I2）和增加（大脑中的前列腺素E），两个饮食组之间无差异。我们认为类花生酸形成的昼夜振荡可能对生物体昼夜时间结构的发展具有重要意义。
