Muakkassa F F, Koruda M J, Ramadan F M, Kawakami M, Meyer A A
Department of Surgery, University of North Carolina, Chapel Hill.
Arch Surg. 1991 Feb;126(2):179-82. doi: 10.1001/archsurg.1991.01410260067009.
Increased mortality from sepsis is associated with high levels of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (PGF1 alpha). Linoleic acid, an n-6 essential fatty acid, is the usual precursor of TXB2 and PGF1 alpha, while fish oil is rich in n-3 essential fatty acid, the precursor of less active moieties. Rats were fed chow, an essential fatty acid-deficient diet, or an essential fatty acid-deficient diet supplemented with linoleic acid or fish oil for 2 weeks. The animals then underwent a sham operation or cecal ligation and puncture to induce sepsis. Six hours later, blood was obtained for analysis. The chow and linoleic acid diets produced significant (twofold to fivefold) increases in levels of both TXB2 and PGF1 alpha after sepsis. The essential fatty acid-deficient diet and fish oil diet protected against increases in levels of TXB2 or PGF1 alpha during sepsis. Dietary restriction of linoleic acid or fish oil supplementation may play an important role in altering the inflammatory mediator response to sepsis.
脓毒症死亡率的增加与血栓素B2（TXB2）和6-酮-前列腺素F1α（PGF1α）的高水平有关。亚油酸，一种n-6必需脂肪酸，是TXB2和PGF1α的常见前体，而鱼油富含n-3必需脂肪酸，是活性较低部分的前体。给大鼠喂食普通饲料、必需脂肪酸缺乏饮食，或补充亚油酸或鱼油的必需脂肪酸缺乏饮食，持续2周。然后对动物进行假手术或盲肠结扎穿刺以诱导脓毒症。6小时后，采集血液进行分析。脓毒症发生后，普通饲料和亚油酸饮食使TXB2和PGF1α水平显著升高（两倍至五倍）。必需脂肪酸缺乏饮食和鱼油饮食可防止脓毒症期间TXB2或PGF1α水平升高。亚油酸的饮食限制或鱼油补充可能在改变对脓毒症的炎症介质反应中起重要作用。
