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伴发淋巴浆细胞淋巴瘤、多发性骨髓瘤和淀粉样变性：一项诊断和治疗挑战。

Concomitant lymphoplasmacytic lymphoma, multiple myeloma, and amyloidosis: A diagnostic and therapeutic challenge.

作者信息

Ceballos Candela, Alburquerque Cristina, Zabalza Amaya, Quispe Iván, Panizo Ángel, Burguete Yolanda, Redondo Ana Margarita, Mateos María Carmen

机构信息

Hematology Department Hospital Universitario de Navarra Pamplona Spain.

Navarra Institute for Health Research (IdiSNA) Pamplona Spain.

出版信息

Clin Case Rep. 2022 Apr 20;10(4):e05769. doi: 10.1002/ccr3.5769. eCollection 2022 Apr.

DOI:10.1002/ccr3.5769
PMID:35474975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9019880/
Abstract

We report a case based on simultaneous occurrence of Waldenström macroglobulinemia, myeloma and amyloidosis as a collision neoplasm. The strangeness and severity of the case presented a diagnostic and therapeutic challenge, which required individualised treatment and close follow-up to achieved stringent complete response.

摘要

我们报告了一例同时发生瓦尔登斯特伦巨球蛋白血症、骨髓瘤和淀粉样变性作为碰撞性肿瘤的病例。该病例的罕见性和严重性带来了诊断和治疗挑战，这需要个体化治疗并密切随访以实现严格的完全缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7125/9019880/6aba929958ed/CCR3-10-e05769-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7125/9019880/6aba929958ed/CCR3-10-e05769-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7125/9019880/6aba929958ed/CCR3-10-e05769-g002.jpg

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本文引用的文献

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Acta Haematol. 2020;143(4):381-387. doi: 10.1159/000506498. Epub 2020 Apr 3.
2
Carfilzomib is an effective upfront treatment in AL amyloidosis patients with peripheral and autonomic neuropathy.卡非佐米是伴有周围和自主神经病的淀粉样变性患者的有效一线治疗药物。
Br J Haematol. 2019 Dec;187(5):638-641. doi: 10.1111/bjh.16122. Epub 2019 Aug 6.
3
Concomitant lymphoplasmacytic lymphoma and plasma cell myeloma, a diagnostic challenge.
伴发淋巴浆细胞淋巴瘤和浆细胞骨髓瘤：一项诊断挑战
Am J Blood Res. 2017 Apr 15;7(2):10-17. eCollection 2017.
4
The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.具有浆细胞分化的小B细胞淋巴瘤的多种面貌及MYD88检测的作用
Virchows Arch. 2016 Mar;468(3):259-75. doi: 10.1007/s00428-015-1858-9. Epub 2015 Oct 10.
5
Dexamethasone, rituximab, and cyclophosphamide as primary treatment of Waldenström macroglobulinemia: final analysis of a phase 2 study.地塞米松、利妥昔单抗和环磷酰胺作为华氏巨球蛋白血症的一线治疗：一项2期研究的最终分析
Blood. 2015 Sep 10;126(11):1392-4. doi: 10.1182/blood-2015-05-647420.
6
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