Medical Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Clinical Sciences Research Institute, Alimentary Tract Research Center, Department of Physiology, The school of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Histol Histopathol. 2022 Sep;37(9):813-824. doi: 10.14670/HH-18-462. Epub 2022 Apr 27.
Nonalcoholic fatty liver disease (NAFLD), as the most common chronic liver disease, is rapidly increasing worldwide. This complex disorder can include simple liver steatosis to more serious stages of nonalcoholic fibrosis and steatohepatitis (NASH). One of the critical concerns in NASH research is selecting and confiding in relying on preclinical animal models and experimental methods that can accurately reflect the situation in human NASH. Recently, creating nutritional models of NASH with a closer dietary pattern in human has been providing reliable, simple, and reproducible tools that hope to create a better landscape for showing the recapitulation of disease pathophysiology. This review focuses on recent research on rodent models (mice, rats, and hamsters) in the induction of the dietary model of NAFLD /NASH. This research tries to compile the different dietary compositions of NASH, time frames required for disease development, and their impact on liver histological features as well as metabolic parameters.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病，在全球范围内迅速增加。这种复杂的疾病可以包括单纯性肝脂肪变性到更严重的非酒精性纤维化和脂肪性肝炎（NASH）阶段。NASH 研究中的一个关键问题是选择和依赖能够准确反映人类 NASH 情况的临床前动物模型和实验方法。最近，用更接近人类饮食模式的方法来创建 NASH 的营养模型，为更好地再现疾病病理生理学提供了可靠、简单和可重复的工具。这篇综述重点介绍了在诱导 NAFLD/NASH 饮食模型方面，啮齿动物模型（小鼠、大鼠和仓鼠）的最新研究进展。本研究试图汇编 NASH 的不同饮食成分、疾病发展所需的时间框架以及它们对肝脏组织学特征和代谢参数的影响。
