State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Chin J Nat Med. 2021 Jan;19(1):12-27. doi: 10.1016/S1875-5364(21)60002-X.
Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. The mechanism of the diaease progression, which is lacking effective therapy, remains obsure. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary. Currently, an increasing number of studies have focused on natural constituents from medicinal plants which have been emerged as a new hope for NASH. This review summarized the pathogenesis of NASH, animal models commonly used, and the promising targets for therapeutics. We also reviewed the natural constituents as potential NASH therapeutic agents.
非酒精性脂肪性肝炎（NASH）是一种常见的临床病症，可导致肝脏疾病的进一步发展。尽管缺乏有效的治疗方法，但该疾病的进展机制仍不清楚。因此，为了开发创新疗法，有必要了解导致疾病发展和进展的致病机制。为了实现这一目标，需要使用能够重现人类疾病的实验动物模型。目前，越来越多的研究集中在药用植物的天然成分上，这些成分已成为 NASH 的新希望。本综述总结了 NASH 的发病机制、常用的动物模型以及有前途的治疗靶点。我们还回顾了天然成分作为潜在的 NASH 治疗药物的作用。
