Department of Pediatric Surgery, Tri-Service General Hospital, National Defense Medical Center, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan.
Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan.
Parasitol Res. 2022 Jul;121(7):1973-1981. doi: 10.1007/s00436-022-07498-4. Epub 2022 Apr 27.
Trichomoniasis is the most prevalent sexually transmitted infection worldwide, and is associated with adverse pregnancy outcomes. However, Trichomonas vaginalis (TV) has received little public health attention, and only limited data are available on prevalence of TV and other Trichomonas-associated syndromes in pregnant women. This study aimed to determine associations between pregnancy and incident trichomoniasis-related diseases. Data of pregnant women were extracted from the National Health Insurance Research Database (NHIRD) of Taiwan. The pregnant cohort included 113,781 women, and cases were randomly matched by age, and index year with those of non-pregnant women (n = 113,781). Risk of incident trichomoniasis-related diseases was also not significantly different between pregnant and non-pregnant women. However, after stratifying by age or level of care, the younger subgroup among pregnant women had a higher risk of incident trichomoniasis-related diseases than did the younger subgroup in non-pregnant women, while the elder subgroup among pregnant women had a lower risk of incident trichomoniasis-related diseases than did the same subgroup in non-pregnant women (all p < 0.05). The higher level of care (medical center) subgroup among pregnant women had a lower risk of incident trichomoniasis-related diseases than did the same subgroup in non-pregnant women. In conclusions, although pregnancy is not significantly associated with risk of trichomoniasis-related diseases, data of the present study support an enhanced high level of medical care for pregnant women, emphasizing the potential of high medical care in reduced incidence of trichomoniasis-related diseases. This may be an effective strategy for reducing various pregnancy complications associated with trichomoniasis-related diseases.
滴虫病是全球最普遍的性传播感染疾病，与不良妊娠结局相关。然而，阴道毛滴虫（TV）在公共卫生领域并未得到太多关注，有关孕妇中 TV 及其他与毛滴虫相关综合征的流行率数据十分有限。本研究旨在确定妊娠与新发滴虫病相关疾病之间的关联。本研究从台湾全民健康保险研究数据库（NHIRD）中提取了孕妇数据。该妊娠队列纳入了 113781 名女性，病例通过年龄和索引年与非妊娠女性（n=113781）随机匹配。妊娠和非妊娠女性新发滴虫病相关疾病的风险并无显著差异。然而，按年龄或医疗保健级别分层后，妊娠组中年龄较小的亚组新发滴虫病相关疾病的风险高于非妊娠组中年龄较小的亚组，而妊娠组中年龄较大的亚组新发滴虫病相关疾病的风险则低于非妊娠组中年龄较大的亚组（均 p<0.05）。妊娠组中医疗保健级别较高（医疗中心）的亚组新发滴虫病相关疾病的风险低于非妊娠组中医疗保健级别相同的亚组（均 p<0.05）。总之，尽管妊娠与新发滴虫病相关疾病的风险无显著关联，但本研究的数据支持为孕妇提供强化的高级别医疗保健，这表明高级别医疗保健可能有助于降低滴虫病相关疾病的发生率。这可能是减少与滴虫病相关疾病相关的各种妊娠并发症的有效策略。
