塔拉甾醇，一种源自海洋真菌的新型维A醇内酯。
Talasteroid, a new withanolide from the marine-derived fungus .
作者信息
Zhang Ya-Hui, Zhao Ying-Jie, Qi Lu, Du Hui-Fang, Cao Fei, Wang Chang-Yun
机构信息
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China.
College of Pharmaceutical Sciences, Hebei University, Baoding, People's Republic of China.
出版信息
Nat Prod Res. 2023 Oct-Nov;37(19):3283-3289. doi: 10.1080/14786419.2022.2070747. Epub 2022 Apr 27.
A new withanolide, talasteroid (), and a known steroid (), along with eight meroterpenoids (-), were obtained from the rice culture of the marine-derived fungus HBU-115. The structure of including its absolute configuration was determined by extensive 1 D and 2 D NMR spectroscopy, and single-crystal X-ray diffraction analysis. Compound represents the first withanolide featuring a 4-substituted 2,3-dimethyl-2-butenolide ring in the side chain. The isolated compounds were evaluated for their antimicrobial and antioxidant activities.
从海洋来源的真菌HBU - 115的大米培养物中获得了一种新的维A醇内酯类化合物——塔拉甾类化合物（）、一种已知的甾体化合物（），以及八种杂萜类化合物（-）。通过广泛的一维和二维核磁共振光谱以及单晶X射线衍射分析确定了的结构，包括其绝对构型。化合物代表了首个在侧链中具有4-取代的2,3-二甲基-2-丁烯内酯环的维A醇内酯类化合物。对分离得到的化合物进行了抗菌和抗氧化活性评估。
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