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石榴内生真菌来源的新倍半萜类衍生物。

New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus .

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt.

Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.

出版信息

Molecules. 2023 Nov 18;28(22):7650. doi: 10.3390/molecules28227650.

DOI:10.3390/molecules28227650
PMID:38005373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10673506/
Abstract

In this study, we report the isolation of two new meroterpenoids, miniolutelide D () and miniolutelide E (13--miniolutelide C) (), along with two meroterpenoidal analogues ( and ) and two phenolic compounds ( and ) from the endophytic fungus derived from fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of and were determined using TDDFT-ECD calculations. Antimicrobial activity was evaluated. Compound displayed significant activity against methicillin-resistant strain ATCC 700699 and moderate activity against strain ATCC 29213.

摘要

在这项研究中，我们报告了两种新的倍半萜类化合物的分离，即 miniolutelide D () 和 miniolutelide E (13--miniolutelide C) ()，以及两种倍半萜类似物 () 和 () 和两种酚类化合物 () 和 ()，它们均来自于果实内生真菌 。通过与文献数据进行比较，采用 MS、1D 和 2D NMR 光谱分析等方法确定了它们的结构。通过 TDDFT-ECD 计算确定了 和 的绝对构型。对其进行了抗菌活性评价。化合物 对耐甲氧西林金黄色葡萄球菌 ATCC 700699 菌株表现出显著的活性，对 菌株 ATCC 29213 表现出中等活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/4eda2916dc8b/molecules-28-07650-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/b3b8ad9940ee/molecules-28-07650-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/6e2b95b46369/molecules-28-07650-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/409a4befdd33/molecules-28-07650-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/65718cc056e5/molecules-28-07650-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/2f005fc18931/molecules-28-07650-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/70dd9d0c95c7/molecules-28-07650-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/4eda2916dc8b/molecules-28-07650-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/b3b8ad9940ee/molecules-28-07650-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/6e2b95b46369/molecules-28-07650-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/409a4befdd33/molecules-28-07650-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/65718cc056e5/molecules-28-07650-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/2f005fc18931/molecules-28-07650-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/70dd9d0c95c7/molecules-28-07650-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/10673506/4eda2916dc8b/molecules-28-07650-g007.jpg

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本文引用的文献

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2
Endophytic fungi: an overview on biotechnological and agronomic potential.内生真菌：生物技术和农业潜力概述。
Braz J Biol. 2022 Jun 6;84:e258557. doi: 10.1590/1519-6984.258557. eCollection 2022.
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Recent Chemical Methodology Advances in the Total Synthesis of Meroterpenoids.近期美拉德萜类化合物全合成中的化学方法学进展。
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A new antibacterial 3,5-dimethylorsellinic acid-based meroterpene from the marine fungus Aspergillus sp. CSYZ-1.一株海洋曲霉 CSYZ-1 来源的新型抗菌 3,5-二甲基orsellinic 酸混合二萜。
Fitoterapia. 2021 Jul;152:104908. doi: 10.1016/j.fitote.2021.104908. Epub 2021 Apr 20.
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New polyketides and diterpenoid derivatives from the fungus Penicillium sclerotiorum GZU-XW03-2 and their anti-inflammatory activity.从真菌青霉属 GZU-XW03-2 中分离得到的新聚酮和二萜类衍生物及其抗炎活性。
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Two Phytotoxins Isolated from the Pathogenic Fungus of the Invasive Weed Xanthium italicum.从入侵杂草豚草的病原菌中分离得到的两种植物毒素。
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