Kakumani Pavan Kumar
Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, NL A1C 5S7, Canada.
Transl Oncol. 2022 Jul;21:101434. doi: 10.1016/j.tranon.2022.101434. Epub 2022 Apr 26.
MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets either as single entities or in complex with other RBPs to control mRNA metabolism. miRNA binding in 3' untranslated regions (3' UTRs) of mRNAs facilitates an intricate network of interactions between miRNA-AGO and RBPs, thus determining the fate of overlapping targets. Here, we review the current knowledge on the interplay between miRNA-AGO and multiple RBPs in different cellular contexts, the rules underlying their synergism and antagonism on target mRNAs, as well as highlight the implications of these regulatory modules in cancer initiation and progression.
微小RNA（miRNA）和RNA结合蛋白（RBP）是真核生物中mRNA翻译和稳定性的重要调节因子。虽然miRNA只能与AGO蛋白（AGO）结合其靶mRNA，但RBP可以作为单个实体或与其他RBP形成复合物直接结合其靶标，以控制mRNA代谢。mRNA的3'非翻译区（3'UTR）中的miRNA结合促进了miRNA-AGO和RBP之间复杂的相互作用网络，从而决定了重叠靶标的命运。在这里，我们综述了关于miRNA-AGO与多种RBP在不同细胞环境中的相互作用、它们对靶mRNA协同和拮抗作用的潜在规则的当前知识，并强调了这些调节模块在癌症发生和发展中的意义。
