Fan T P, Cox J H, Chisholm P M
Transplantation. 1987 Mar;43(3):343-5. doi: 10.1097/00007890-198703000-00004.
Four cyclo-oxygenase products (COP) of arachidonate were measured in tissue homogenates of rat cardiac allografts at intervals after transplantation. In rejecting graft tissue, there was a progressive decrease in the levels of prostaglandin E2 (PGE2) and PGF2 alpha from the time of grafting, which was accompanied by a rise in the levels of prostacyclin (PGI2, measured as its stable hydrolysis product 6-oxo-PGF1 alpha) and thromboxane A2 (TxA2, measured as its stable hydrolysis product TxB2). When the level of each individual COP in rejecting graft tissue was expressed as a percentage of the total COP measured, PGI2 and TxA2 increased from 9% to 36% and from 7% to 25%, respectively, from day three after grafting until the time of graft rejection. In contrast to these changes in COP levels in rejecting grafts, the levels of all four COP in nonrejecting allografts maintained by treatment of the graft recipients with cyclosporine remained normal--i.e., comparable to the levels in the recipients' own hearts.
在移植后的不同时间间隔，对大鼠心脏同种异体移植组织匀浆中的四种花生四烯酸环氧化酶产物（COP）进行了测定。在发生排斥反应的移植组织中，从移植时起，前列腺素E2（PGE2）和前列腺素F2α（PGF2α）的水平逐渐下降，同时前列环素（PGI2，以其稳定水解产物6-氧代-PGF1α测定）和血栓素A2（TxA2，以其稳定水解产物TXB2测定）的水平升高。当将发生排斥反应的移植组织中每种COP的水平表示为所测总COP的百分比时，从移植后第三天到移植排斥发生时，PGI2和TxA2分别从9%增加到36%和从7%增加到25%。与发生排斥反应的移植组织中COP水平的这些变化相反，通过用环孢素治疗移植受者而维持的未发生排斥反应的同种异体移植组织中，所有四种COP的水平均保持正常，即与受者自身心脏中的水平相当。
