免疫刺激剂和抗炎剂对组织培养中小鼠胚胎成纤维细胞前列腺素E2、F2α、前列环素（PGI2）和血栓素A2（TXA2）生物合成的影响。
Effect of immunostimulating and anti-inflammatory agents on the biosynthesis of prostaglandins E2, F2 alpha, prostacyclin (PGI2) and thromboxane a2 (TXA2) by mouse embryo fibroblasts in tissue culture.
作者信息
Weinling P, Homo-Delarche F
出版信息
Br J Dermatol. 1983 Jul;109 Suppl 25:130-2. doi: 10.1111/j.1365-2133.1983.tb06824.x.
Experiments performed in cultures of mouse embryo fibroblasts have shown that dexamethasone (10(-6) M) significantly inhibits the production of PGE2 and PGI2 but only moderately inhibits that of PGF2 alpha. Conversely, lipopolysacharide treatment (5 micrograms/ml) markedly stimulated the secretion of PGE2 and PGI2 and only slightly that of PGF2 alpha. In these cultures, the secretion of TXA2 remained unaffected either in the presence of dexamethasone or LPS.
在小鼠胚胎成纤维细胞培养物中进行的实验表明，地塞米松（10⁻⁶ M）显著抑制前列腺素E2（PGE2）和前列环素（PGI2）的产生，但仅适度抑制前列腺素F2α（PGF2α）的产生。相反，脂多糖处理（5微克/毫升）显著刺激PGE2和PGI2的分泌，而对PGF2α的分泌仅有轻微刺激。在这些培养物中，无论存在地塞米松还是脂多糖，血栓素A2（TXA2）的分泌均不受影响。
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