Fry Jean L, Munson Brooke D, Thompson Katherine L, Fry Christopher S, Paddon-Jones Douglas, Arentson-Lantz Emily J
Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, 40536-0200, USA.
Dr. Bing Zhang Department of Statistics, University of Kentucky, Lexington, KY, 40536-0082, USA.
Sci Rep. 2022 Apr 27;12(1):6897. doi: 10.1038/s41598-022-10683-1.
Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest.
由于药物、身体活动不足和基础疾病等因素，住院患者发生高血糖的风险增加，这会导致发病率和死亡率上升。不幸的是，临床医生用于前瞻性识别高危患者的工具有限。我们评估了与2型糖尿病发生相关的10种常见基因变异预测糖代谢受损的能力。我们的研究模型是对一组健康的老年人（n = 31，65±8岁）进行模拟住院治疗（7天卧床休息方案、标准化饮食和身体活动不足），其基线空腹血糖<100 mg/dL。参与者在基线和卧床休息后完成了标准的75 g口服葡萄糖耐量试验（OGTT）。卧床休息会使2小时OGTT血糖和胰岛素升高，且与基因变异无关。在多元回归模型中，转录因子7样2（TCF7L2）rs7903146 T等位基因预测2小时OGTT血糖升高（p = 0.039）。我们发现，在7天卧床休息后，TCF7L2 rs7903146 T等位基因会使非糖尿病老年人出现糖耐量丧失的风险增加。
